Abstract: Objective To observe the changes of blood T-cell subpopulations,ASO,IL-6 and IL-8 in children with Tourette's syndrome (TS) and explore the pathogenesis. Methods T-cell subpopulations and concentration of IL-6,IL-8,ASO were measured in 32 children with TS and 30 normal children using SAP and ELISA.Yale global tic severity scale(YGTSS) was used to evaluate the severity of tic disorder in children with GTS. Results The numbers of CD⁺₃,CD⁺₄ and CD⁺₈ cells were no significant differences between 32 children with Tourette’s syndrome and 30 normal children(P>0.05),and the levels of IL-6[(68.12±28.13)ng/L] and ASO[(351.4±27.6)kU/L]in serum of children with Tourette's syndrome were significantly higher than those in normal children[(240.8±20.9)kU/L,(48.48±26.21)ng/L](P<0.05).No statistical significance of IL-8 was found in two groups. Conclusion There may be disfunction in humoral immunity in Tourette's syndrome.The pathogenesis of Tourette's syndrome may should be improved in future.

Key words: Tourette&apos, s syndrome, ASO, IL-6, IL-8, T-cell subpopulations

摘要： 目的 观察抽动秽语综合征(Tourettes' syndrome,TS)患者抽动严重程度和抗链球菌溶血素O(ASO)、T淋巴细胞亚群、血清IL-6、IL-8水平的关系,以探讨其可能发病机理。 方法 对32例抽动秽语综合征患者和30例正常儿童分别采用间接免疫SAP花环法检测T淋巴细胞亚群和ELISE法检测血清IL-6和IL-8水平。32例患者还用YALE综合抽动严重程度量表(YGTSS)进行了调查。 结果 抽动秽语综合征患者T淋巴细胞亚群和对照组比较差异无统计学意义(P>0.05),患者组血清ASO、IL-6水平[分别为(351.4±27.6)kU/L,(68.12±28.13)ng/L]明显高于对照组[(240.8±20.9)kU/L,(48.48±26.21)ng/L](P<0.05),而两组IL-8水平分别为[(63.28±26.63);(56.84±22.78)ng/L]差异无统计学意义(P>0.05)。 结论 抽动秽语综合征患者可能存在免疫学方面的改变,其免疫学机制还有待进一步深入探讨。

关键词: 抽动秽语综合征, 抗链球菌溶血素O, IL-6, IL-8, T淋巴细胞亚群