doi:10.11852/zgetbjzz2014-22-07-14

Abstract

摘要： 钙是人体内重要的常量元素, 它主要来源于食物。通过肠道钙的吸收、肾脏钙的重吸收和骨的重建维持体内钙的稳态。维生素D是影响肠道钙吸收的主要因素, 它在人体内经过一系列的代谢过程, 生成具有极高生物学活性的1, 25-(OH)2D, 进入细胞中与维生素D受体结合, 从基因水平调节钙吸收途径的多个位点。笔者主要对肠道钙吸收的跨细胞途径和细胞旁途径的多个维生素D调节位点进行综述。

关键词: 钙, 维生素D, 瞬时感受器电位香草素受体6, 钙结合蛋白, 钙泵

CLC Number:

R722

刘锦, 张巍. 维生素D调节肠道钙吸收的研究进展[J]. 中国儿童保健杂志, 2014, 22(7): 713-715.

[1] Christakos S, Dhawan P, Porta A, et al.Vitamin D and intestinal calcium absorption[J].Mol Cell Endocrinol, 2011, 347(1-2):25-29.
[2] Bronner F.Recent development in intestinal calcium absorption[J].Nutr Rev, 2008, 67(2):109-113.
[3] Christakos S.Recent advances in our understanding of 1, 25-dihydroxyvitamin D₃ regulation of intestinal calcium absorption[J].Arch Biochem Biophys, 2012, 523:73-76.
[4] Christakos S.Mechanism of action of 1, 25-dihydroxyvitamin D₃ on intestinal calcium absorption[J].Rev Endocr Metab Disord, 2012, 523:13:39-44.
[5] James CF, Ryan D.Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors[J].Crit Rev Clin Lab Sci, 2010, 47(4):181-195.
[6] Bronner F.Mechanisms of Intestinal Calcium Absorption[J].J Cell Biochem, 2003, 88:387-393.
[7] Pérez AV, Picotto G, Carpentieri AR, et al.Minireview on Regulation of Intestinal Calcium Absorption[J].Digestion, 2008, 77:22-34.
[8] Alisio A, Canas F, de Bronia DH, et al.Effect of vitamin D deficiency on lipid composition and calcium transport in basolateral membrane vesicles from chick intestine.Biochem Mol Biol Int, 1997, 42:339-347.
[9] Haussler MR, Jurutka PW, Mizwicki M, et al.Vitamin D receptor(VDR)-mediated actions of 1, 25(OH)₂ vitamin D₃:Genomic and non-genomic mechanisms[J].Best Pract Res Cl En, 2011, 25:543-559.
[10] Xue Y, Fleet JC.Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice[J].Gastroenterology, 2009, 136(4):1317-1322.
[11] Inho HWANG, Eui-Man JUNG, Hyun YANG, et al.Tissue-specific expression of the calcium transporter genes TRPV5, TRPV6, NCX1, and PMCA1b in the duodenum, kidney and heart of equus caballus[J].J Vet Med Sci, 2011, 73(11):1437-1444.
[12] Lieben L, Benn BS, Ajibade D, et al.Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis[J].Bone, 2010, 47(2):301-308.
[13] Kutuzovaa GD, Sundersingha F, Vaughana J, et al.TRPV6 is not required for 1, 25-dihydroxyvitamin D₃-induced intestinal calcium absorption in vivo[J].PNAS, 2008, 105(50):19655-19659. [14] Benn BS, Ajibade D, Porta A, et al.Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k[J].Endocrinology, 2008, 149:3196-205.
[15] Cui M, Fleet J.Transgenic overexpression of human TRPV6 in intestine increases calcium absorption efficiency and improves bone mass in mice[J].J Bone Miner Res, 2010, 25(S):59-70.
[16] Meyer MB, Watanuki M, Kim S, et al.The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1, 25-dihydroxyvitamin D₃ in intestinal cells[J].Mol Endocrinol, 2006, 20:1447-1461.
[17] Balesaria S, Sangha S, Walters JRF.Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption[J].Am J Physiol Gastrointest Liver Physiol, 2009, 297:G1193-G1197.
[18] Haussler MR, Whitfield GK, Kaneko I, et al.Molecular mechanisms of vitamin D action[J].Calcif Tissue Int, 2013, 92:77-98.
[19] Kellett GL.Alternative perspective on intestinal calcium absorption: proposed complementary actions of Cav1.3 and TRPV6[J].Nutr Rev, 2011, 69(7):347-370.
[20] Fujita H, Sugimoto K, Inatomi S, et al.Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca⁺₂ absorption between enterocytes[J].Mol Biol Cell, 2008, 19(5):1912-1921.
[21] Christakos S, Dhawan P, Ajibade D, et al.Mechanisms involved in vitamin D mediated intestinal calcium absorption and in non-classical actions of vitamin D[J].J Steroid Biochem Mol Biol, 2010, 121:183-187.

维生素D调节肠道钙吸收的研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	LI Xiaoqiang, GUO Zhirong, MA Zhengying, WANG Lixia, SHEN Wei. Feeding index and its influencing factors of preterm and low birth weight infants [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1256-1260.
[2]	CUI Pengyuan, LI Guiping. Causal relationship between neonatalhy perbilirubinemia and tic disorder by Mendelian randomization [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1116-1121.
[3]	. [J]. Chinese Journal of Child Health Care, 2024, 32(9): 929-933.
[4]	XIE Haixia, LUO Hongxia, LIU Haixia, SHAO Qinnan, FENG Guojun, WEN Yalan. Impact of histological chorioamnioitis on complications and neurodevelopment in premature infants at 1 year of age [J]. Chinese Journal of Child Health Care, 2024, 32(9): 947-952.
[5]	WEI Ping, WEI Jishan, HUANG Xuhua, ZHANG Yuxing, LIU Xianghong, HE Zhongbiao, MO Jingyuan, HUANG Zengshuai, YU Qun. Application of cardiac auscultation, pulse oximetry combine with oxygen inhalation in screening neonatal congenital heart disease in Guangxi Province [J]. Chinese Journal of Child Health Care, 2024, 32(9): 1034-1039.
[6]	WANG Xiuying, ZHENG Xiaoqin, ZOU Linli, DING Ling, FAN Ling, NIE Jing. Comparison of early catch-up growth among different types of small for gestational age infants and relevant influencing factors [J]. Chinese Journal of Child Health Care, 2024, 32(6): 613-618.
[7]	WANG Yinfei, YIN Qin, ZENG Sijie, SUN Lei, YAN Qinhui, SHENG Xiaojing. Differences in exosome miRNAs in human breast milk between preterm and full-term infants [J]. Chinese Journal of Child Health Care, 2024, 32(4): 377-383.
[8]	YU Hanshu, SUN Ruizhen, YANG Yanling, SU Yuehua, FU Zhongying. Effectiveness of extensively hydrolyzed formula in treating feeding intolerance in preterm infants [J]. Chinese Journal of Child Health Care, 2024, 32(4): 456-459.
[9]	HUANG Wanyi, ZHANG Youxiang, OU Qiaoqun, LIU Yuanchun, GUO Jiayu. Effects of gestational diabetes mellitus on brain development and miRNAs expression profile in neonatal mice [J]. Chinese Journal of Child Health Care, 2024, 32(2): 154-158.
[10]	LU Anfeng, HUANG Peilu, BI Lei, HUANG Guosheng, HUANG Haiyan. Physical and neuropsychological development of the offspring born to mother with gestational diabetes mellitus at 2 years old [J]. Chinese Journal of Child Health Care, 2024, 32(2): 208-211.
[11]	NING Yue, LUO Liyan, DUAN Jiang, XIE Yunbo, QI Zhiye, ZHANG Caiying, YANG Li, ZHONG Qinghua. Effects of different fortified feeding methods on the nutrient metabolism and growth rate of very low birth weight preterm infants [J]. Chinese Journal of Child Health Care, 2024, 32(1): 84-88.
[12]	CUI Hong. Premature infants need to be vigilant about spastic cerebral palsy [J]. Chinese Journal of Child Health Care, 2023, 31(11): 1165-1167.
[13]	WU Tong, JI Hong. Research advance in the relationship between hyperoxia and immature brain injury [J]. Chinese Journal of Child Health Care, 2023, 31(11): 1214-1218.
[14]	MA Hongfang, XUE Jiang, LIANG Shuang. Protective effect and mechanism of insulin-like growth factor 1 in preterm infants with white matter damage [J]. Chinese Journal of Child Health Care, 2023, 31(11): 1219-1224.
[15]	YOU Fang. Application of individualized vitamin D supplementation in very preterm infants [J]. Chinese Journal of Child Health Care, 2023, 31(10): 1127-1131.