Research progress of the microbiota-gut-brain axis in autism spectrum disorder and treatment

doi:10.11852/zgetbjzz2024-1431

Abstract

Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, and its prevalence has shown a sustained upward trend over the past two decades.Emerging evidence suggests a bidirectional regulatory mechanism between ASD-related behavioral manifestations and the microbiota-gut-brain axis (MGB axis), with numerous studies reporting alterations in gut microbiota composition within this axis.This article reviews the therapeutic effects of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation on ASD at varying dosages and treatment durations.Post-intervention assessments using standardized scales, including the Autism Treatment Evaluation Checklist (ATEC), Childhood Autism Rating Scale (CARS), and Autism Behavior Checklist-Japanese Version (ABC-J), demonstrated symptomatic improvements in individuals with ASD.However, all four interventions share limitations, such as a lack of large-scale clinical data and inadequate personalization of dosage and treatment duration to address the heterogeneity of ASD patients.Future research is warranted to validate the efficacy of these microbiota-targeted interventions and optimize treatment protocols for broader clinical application.

Key words: autism spectrum disorder, microbiota-gut-brain axis, fecal microbiota transplantation, treatment

摘要： 孤独症谱系障碍(ASD)是一种复杂的神经系统发育障碍性疾病,近20年来其患病率呈持续增长趋势。ASD患者的行为表现可能与微生物-肠-脑轴(BGM轴)存在双向调节机制,而BGM轴中肠道微生物群改变已有很多报道。因此,本文总结了不同剂量和疗程的益生菌、益生元、合生元和粪便微生物群移植治疗ASD的效果,ASD治疗评估量表(ATEC)、儿童孤独症评定量表(CARS)、ASD患者异常行为检查量表-日本版(ABC-J)等评估指标显示干预后ASD患者症状均有改善,但4种疗法仍有缺少大样本临床数据的不足,以及针对ASD患者异质性的个性化剂量和疗程调整不充分的短板。未来仍需要对这些针对微生物群的干预措施的有效性和优化方案进一步研究。

关键词: 孤独症谱系障碍, 微生物-肠-脑轴, 粪便微生物群移植, 治疗

CLC Number:

R749.94

LING Mei, WANG Yuehong, LI Na, XIONG Yuhong, YANG Shu, XU Guifeng. Research progress of the microbiota-gut-brain axis in autism spectrum disorder and treatment[J]. Chinese Journal of Child Health Care, 2025, 33(7): 778-782.

凌梅, 汪月红, 李娜, 熊玉红, 杨舒, 徐桂凤. 孤独症谱系障碍微生物-肠-脑轴研究进展[J]. 中国儿童保健杂志, 2025, 33(7): 778-782.

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