Advances in mechanisms underlying autism spectrum disorder in offspring induced by maternal immune activation

doi:10.11852/zgetbjzz2024-0784

Abstract

Abstract: Autism spectrum disorder(ASD) is a neurodevelopmental disorder primarily characterized by social impairments and repetitive, stereotyped behaviors, resulting from the combined effects of genetic and environmental factors. Maternal immune activation (MIA) has been recognized as one of the significant risk factors for the occurrence of ASD in offspring. Recent studies have implicated MIA in metabolic disorder, disrupted gut microbiota, epigenetic alterations, and neuroinflammation associated with ASD. However, the specific underlying mechanisms remain elusive. Therefore, this study aims to provide theoretical support for the etiology research of ASD by comprehensively reviewing the mechanisms pertaining to the elevated risk of ASD associated with MIA.

Key words: autism spectrum disorder, maternal immune activation, metabolism, gut microbiota, epigenetics, neuroinflammation

摘要： 孤独症谱系障碍(ASD)是一组以社交障碍和重复刻板行为为核心症状的神经发育障碍性疾病,由遗传及环境因素共同作用而成。母体免疫激活(MIA)被认为是ASD发生的重要危险因素之一。近年来关于MIA导致子代ASD发生的相关机制研究发现,ASD的发病可能与MIA诱导的代谢失调、肠道菌群紊乱、表观遗传改变及神经炎症等有关,但其机制尚不十分明确,因此本文拟综述MIA导致子代ASD发病风险增高的相关机制,为ASD的病因及发病机制研究提供一定的理论支持。

关键词: 孤独症谱系障碍, 母体免疫激活, 代谢, 肠道菌群, 表观遗传, 神经炎症

CLC Number:

R179

WANG Jin, SHEN Kexin, CHEN Jie, DING Yuan. Advances in mechanisms underlying autism spectrum disorder in offspring induced by maternal immune activation[J]. Chinese Journal of Child Health Care, 2025, 33(11): 1252-1255.

王琎, 沈珂馨, 陈洁, 丁媛. 孕期免疫激活致子代孤独症谱系障碍发生机制的研究进展[J]. 中国儿童保健杂志, 2025, 33(11): 1252-1255.

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