Abstract: Objective To assess possible correlations between serum growth hormone(GH) and ghrelin values during the GH provocative tests in children with short stature. Methods Fifty seven prepubertal children with short stature were recruited in the study.Using the results of two GH-provocative tests(L-dopa and insulin),the children with short stature were divided into two groups:GHD and NGH.In both groups,serum GH and ghrelin levels were determined and possible correlations between GH and ghrelin values were assessed during the GH provocative tests. Results 1)Serum ghrelin levels had no statistical differences between GHD and NGH groups(P>0.05)during the GH provocative tests,either baseline ghrelin or peak ghrelin.2)No correlations were observed between ghrelin and GH levels either baseline or peak levels,both in GHD group and NGH group.3)Serum ghrelin levels were correlated with height,weight and BMI.But weight was the independent determinant on serum ghrelin levels. Conclusions No significantly correlations are observed between the ghrelin and GH levels in short stature children during the GH provocative tests.The results suggest that ghrelin do not play a main role during the control of GH secretion,although ghrelin possessing a strong growth hormone-releasing activity.

Key words: ghrelin, growth hormone, children with short stature, GH provocative tests

摘要： 目的 探讨矮小儿童生长激素激发试验过程中血清ghrelin与血清生长激素(growth hormone,GH)之间的关系。方法 以57例青春期前的矮小儿童为研究对象,根据两种生长激素联合激发试验结果(左旋多巴和胰岛素)将矮小儿童分为生长激素缺乏(growth hormone deficiency,GHD)组和非生长激素缺乏(normal growth hormone,NGH)组,测定矮小儿童生长激素激发试验过程中0、30、60、90 min的血清GH值和ghrelin值,进行对比及相关分析。结果 1)GHD组与NGH组之间,虽然血清GH值差异明显,但两组间基线(0 min)ghrelin值和ghrelin峰值之间差异均无明显统计学意义(P>0.05);2)不论是GHD组还是NGH组,基线ghrelin和基线GH之间,ghrelin峰值与GH峰值之间无相关(P>0.05);3)血清ghrelin值与身高、体重、BMI相关,其中体重是独立影响因素。 结论 本研究中矮小儿童血清ghrelin水平与GH之间无明显相关;虽然ghrelin具有很强的促进GH分泌的作用,但在调控GH分泌过程中并不起主要作用。

关键词: Ghrelin, 生长激素, 矮小儿童, 生长激素激发试验