Analysis the risk factors of 893 cases of neonatal respiratory distress syndrome
- QU Wen-wen1,2,FAN Han-xiao1,XIE Lu1,HAN Xiao1,YIN Xiao-juan1,2
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Abstract
Objective To investigate the high risk factors of neonatal respiratory distress syndrome (RDS). Methods A retrospective data analysis method,893 cases of RDS infants were chosen in the neonatal intensive care unit in Bayi Hospital from January 2007 to October 2012.Depending on gestational age,they were divided into full-term children group (148 cases) and preterm children group(745 cases).Compared the gender,gestational age,birth weight,mode of delivery,asphyxia,placental problem,premature rupture of fetal membranes,intrauterine infection,meconium aspiration syndrome,maternal diabetes,maternal hypertension within the group and between groups,the data were analyzed by SPSS 19.0. Results Single factor analysis indicated that male,cesarean section,intrauterine infection,intrauterine distress were associated with RDS in full-term infants.Premature birth,premature rupture of membranes,maternal hypertension,asphyxia were risk factors of RDS in the preterm infants.Multivariate logistic regression analysis showed high risk factors and the role of various factors in the RDS disease occur in the size were cesarean section> intrauterine infection> maternal hypertension> birth weight> maternal diabetes> birth asphyxia(OR was for 71.136,66.117,65.824,38.565,4.935,1.940 respectively). Conclusions Many high risk factors are associated with RDS,premature birth,cesarean delivery,intrauterine infection,birth asphyxia,maternal hypertension,maternal diabetes are closely associated with RDS.These clinical factors should be given more attention.
Key words
neonatal respiratory distress syndrome / high risk factors / Logistic regression analysis
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References
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[4] de Abreu LC,Valenti VE,de Oliveira AG,et al.Chest associated to motor physiotherapy improves cardiovascular variables in newborns with respiratory distress syndrome[J].Int Arch Med,2011,4:37-45.
[5] Mazela J,Merritt TA,Gadzinowski J,et al.Evolution of pulmonary surfactants for the treatment of neonatal respiratory distress syndrome and paediatric lung disease[J].Acta Paediatr,2006,95(9):1036-1048.
[6] Clark RH.The epidemiology of respiratory failure in neonates born at an estimated gestational age of 34 weeks or more[J].J Perinatol,2005,25(4):251-257.
[7] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版.北京:人民卫生出版社,2011:395-397.
[8] Clark RH.The epidemiology of respiratory failure in neonates born at an estimated gestational age of 34 weeks or more[J].J Perinatol,2005,25:251-257.
[9] Curstedt T,Johansson J.New synthetic surfactants-basic science[J].Biol Neonate,2005,87:332-337.
[10] Clair St C,Norwitz ER,Woensdregt K,et al.The probability of neonatal respiratory distress syndrome as a function of gestational age and lecithin/sphingomyelin ratio[J].Am J Perinatol,2008,25(8):473-480.
[11] Lyra PPR,Diniz EMA,Abe-Sandes K,et al.Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome[J].Braz J Med Biol Res,2011,44(1):66-72.
[12] Sweet DG,Halliday HL.The use of surfactants in 2009[J].Arch Dis Child Educ Pract Ed,2009,94:78-83.
[13] Abdel-Latif ME,Oei J,Ward M,et al.Galvanised by a respiratory distress diagnosis[J].Arch Dis Child Educ Pract Ed,2008,93:112-119.
[14] Yin XJ,Li LH,Fan HX,et al.Correlation between surfactant protein B mRNA expression and neonatal respiratory distress syndrome[J].Exp Ther Med,2012,4(5):815-819.
[15] Hanvas A,Cole FS,Nogee LM.Genetic disorders of surfactant proteins[J].Neonatology,2007,91:311-317.
