Risk factors for hypoxic-ischemic encephalopathy in asphyxiated newborn infants
- LIN Li, YANG Yu-li, XIE Fei-yan, LU Mei-juan
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Abstract
【Objective】 To determine the risk factors for hypoxic-ischemic encephalopathy (HIE) in asphyxiated newborn infants. 【Methods】 A retrospective study of 98 asphyxiated newborn infants (gestational age ≥ 37 weeks) in our hospital from January 2008 till the end of June 2009, and 32 newborn infants were complicated by HIE. The clinical data of the HIE group (n=32) were compared with those of the HIE negative group (n=66). 【Results】 The incidences inappropriate antenatal care, prolapsed cord, abruptio placenta, male and post-term gestation in the HIE group were significantly higher than those in HIE negative group (P<0.05), the 1 and 5-minute Apgar scores were significantly lower in the HIE group than those in HIE negative group (P<0.05), a 5-minute Apgar score of 3 or less in infants had a high risk of neonatal death in HIE infants and asphyxiated infants (P<0.05). Inappropriate antenatal care, 1min and 5 min Apgar score had significant relation to HIE occurrence after birth asphyxia (P<0.05). 【Conclusion】 It is very important for the prevention of HIE that these risk factors should be highly concerned to minimize birth asphyxia.
Key words
asphyxia / hypoxic-ischemic encephalopathy / risk factors / newborn Infants
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References
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[2] 中华医学会儿科分会新生儿学组. 新生儿缺血缺氧性脑病诊断标准[M]. 中华儿科杂志, 2005, 43 (8): 584-585.
[3] 陈群, 周长怀, 朱海燕, 等. 新生儿窒息与缺氧缺血性脑病的关系与随访[M]. 中国误诊学杂志, 2009, 9(25): 6100-6101.
[4] Palsdottir K, Dagbjartsson A, Thorkelsson T, et al. Birth asphyxia and hypoxic ischemic encephalopathy, incidence and obstetric risk factors[J]. Laeknabladid, 2007, 93(9):595-601.
[5] 蔡清, 薛辛东, 富建华. 新生儿缺氧缺血性脑病研究现状及进展[J]. 中国实用儿科杂志, 2009, 24(12): 968-971.
[6] Butt TK, Farooqui R, Khan MA. Risk factors for hypoxic ischemic encephalopathy in children[J]. J Coll Physicians Surg Pak, 2008, 18(7): 428-432.
[7] 李青, 张双琴. 新生儿缺氧缺血性脑病64例的产科因素分析[J]. 第四军医大学学报, 2009, 30(2):171-173.
[8] Hubacek JA, Stuber F, Frohlich D, et al. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis[J]. Crit Care Med, 2001, 29(3):557-561.
[9] Futrakul S, Deerojanawong J, Prapphal N. Risk factors of bronchial hyperresponsiveness in children with wheezing associated respiratory infection[J]. Pediatr Pulmonolo, 2005, 40(1): 81-87.
[10] Papile LA. The Apgar score in the 21st century[J]. N Engl J Med,2001,344(7):519-520.
[11] Casey BM, McIntire DD, Leveno KJ. The continuing value of the Apgar score for the assessment of newborn infants[J]. N Engl J Med, 2001, 344(7): 467-471.
[12] Laptook AR, Shankaran S, Ambalavanan N, et al. Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy[J]. Pediatrics, 2009, 124(6): 1619-1626.
