Differences of fatty acid composition between children with high and low intelligence quotient and the influence of dietary supply of n-3 fatty acids on children with low intelligence quotient in Yuyao

Abstract

Abstract: 【Objective】 To investigate the differences of fatty acid(FA) composition between children with high(>135) and low(<90) intelligence quotient(IQ) and the influence of dietary supply of n-3 polyunsaturated fatty acids(PUFAs) on children with low IQ(<90) in Yuyao. 【Methods】 In two common primary schools of Yuyao, students from Grade two to Grade five were selected to two groups(IQ >135 and IQ<90) by intelligence test(Combined Raven Test, CRT). Their blood were collected and the FA composition was analyzed by capillary gas chromatography. In the IQ<90 group, students were randomly assigned to receive either control food or food supplemented with n-3 PUFAs according to the randomized controlled trial(RCT) rules. Data of fatty acid composition were collected before and after the dietary supplementation. 【Results】 There were significant differences of the long-chain polyunsaturated fatty acids(LC-PUFAs) composition in these students with high and low intelligence quotient. Among students with high IQ, arachidonic acid (AA), eicosapentaenoic acid(EPA), docosahexaenoic acid(DHA) and n-3 PUFAs levels were higher(P<0.001 or <0.05) than students with low IQ, while linoleic acid(LA) and the n-6/n-3 ratio was lower(P＜0.05 or ＜0.01) than students with low IQ. In the IQ<90 group, α-linolenic acid(ALA), EPA, DHA and n-3 PUFAs level were significantly increased(P<0.05 or <0.001) and the n-6/n-3 ratio was decreased(P<0.001) after the n-3 PUFAs supplementation. 【Conclusions】 The students with high IQ had higher AA and DHA level and lower n-6/n-3 ratio. And the supplementation of n-3 PUFAs could improve their FA level in students with IQ<90, making it close to those IQ>135. We hope more studies will concentrate on the functional outcomes after the FA improvement in those IQ<90.

Key words: long-chain polyunsaturated fatty acids, randomized controlled trial, school children, intelligence quotient

摘要： 【目的】研究高智商(IQ>135)与低智商(IQ<90)学生体内n-6与n-3脂肪酸水平差异,以及补充n-3类多不饱和脂肪酸(polyunsaturated fatty acids, PUFAs)对IQ＜90的学生体内脂肪酸组成的影响作用。【方法】整群抽取浙江余姚中等水平乡镇的2所普通小学,通过智力测定筛选出IQ＜90以及＞135的学生两组,采集静脉血分析其脂肪酸组成。采用随机对照研究方法,将IQ＜90的学生进行随机分组,分别给予为期3个月的干预食物(富含n-3 PUFAs)与对照食物,对干预前后的血脂肪酸水平数据进行比较。【结果】智商高低学生体内脂肪酸水平存在明显差异:IQ＞135的学生其体内花生四稀酸(arachidonic acid, AA)、二十碳五烯酸(eicosapentaenoic acid,EPA)、二十二碳六烯酸(docosahexaenoic acid, DHA)以及n-3 PUFAs水平明显高于IQ＜90的学生(P<0.001或＜0.05);而亚油酸(linoleic acid, LA )水平以及n-6/n-3 PUFAs比例明显低于IQ＜90的学生(P＜0.05或＜0.01)。同时,在对IQ＜90的学生补充富含n-3 PUFAs的食物后,其体内脂肪酸组成也发生显著变化,表现为:α-亚麻酸(α-linolenic acid,ALA)、EPA、DHA以及n-3 PUFAs水平显著提高(P<0.05或<0.001),而n-6/n-3 PUFAs比例明显下降(P<0.001)。【结论】智商高的学生体内AA及DHA水平较高而n-6/n-3 PUFAs比例较低。同时,对智商低的学生补充n-3 PUFAs可以改变其体内的脂肪酸组成,使其更为接近高智商学生体内的脂肪酸组成。

关键词: 长链多不饱和脂肪酸, 随机对照研究, 学龄儿童, 智商

CLC Number:

R179

ZHOU Ting-ting, PENG Yong-mei, WANG Yan-yan, MA Li-ping, YUAN Dong-juan, KANG Jing-xuan. Differences of fatty acid composition between children with high and low intelligence quotient and the influence of dietary supply of n-3 fatty acids on children with low intelligence quotient in Yuyao[J]. journal1, 2011, 19(2): 124-127.

周婷婷,元冬娟,康景轩. 不同智力水平人群n-3 PUFAs差异及膳食补充对体内脂肪酸组成的影响研究[J]. 中国儿童保健杂志, 2011, 19(2): 124-127.

References

[1] 周韫珍.脂类[M]∥葛可佑.中国营养科学全书.北京:人民卫生出版社,2004:51-67.
[2] Fleith M, Clandinin MT. Dietary PUFA for preterm and term infants: review of clinical studies[J]. Crit Rev Food Sci Nutr,2005,45(3):205-229.
[3] Curtis LT, Patel K. Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder(ADHD): a review[J]. J Altern Complement Med,2008,14(1):79-85.
[4] Brenna JT, Diau GY. The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition[J]. Prostaglandins Leukot Essent Fatty Acids,2007,77(5-6):247-250.
[5] Antalis CJ, Stevens LJ, Campbell M, et al. Omega-3 fatty acid status in attention-deficit/hyperactivity disorder[J]. Prostaglandins Leukot Essent Fatty Acids,2006,75(4-5):299-308.
[6] Morse NL. A meta-analysis of blood fatty acids in people with learning disorders with particular interest in arachidonic acid[J]. Prostaglandins Leukot Essent Fatty Acids,2009,81(5):373-389.
[7] Gale CR, Robinson SM, Godfrey KM, et al. Oily fish intake during pregnancy-association with lower hyperactivity but not with higher full-scale IQ in offspring[J]. J Child Psychol Psychiatry,2008,49(10):1061-1068.
[8] Helland IB, Smith L, Blomén B, et al. Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age[J]. Pediatrics,2008,122(2):e472-e479.
[9] Whalley LJ, Fox HC, Wahle KW, et al. Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids[J]. Am J Clin Nutr,2004,80(6):1650-1657.
[10] Birch EE, Castaneda YS, Wheaton DH, et al. Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo[J]. Am J Clin Nutr,2005,81(4):871-879.
[11] Sorgi PJ, Hallowell EM, Hutchins HL, et al. Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder[J]. Nutr J,2007,6:16-20.
[12] Food and Agriculture Organization (FAO). Fats and Oils in Human Nutrition: Report of a Joint Expert Consultation[N]. Food and Nutrition Paper,1994,57-60.
[13] Brenna JT, Salem NJr, Sinclair AJ, et al. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans[J]. Prostaglandins Leukot Essent Fatty Acids,2009,80(2):85-91.
[14] Richardson AJ, Montgomery P. The oxford-durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder[J]. Pediatrics,2005,115(5):1360-1366.
[15] Sinn N, Bryan J. Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD[J]. J Dev Behav Pediatr,2007,28(2):82-91.
[16] Kirby A, Woodward A, Jackson S, et al. Childrens' learning and behaviour and the association with cheek cell polyunsaturated fatty acid levels[J]. Res Dev Disabil,2010,31(3):731-742.