Correlation between feeding methods and gastrointestinal symptoms in 1-month-old infants

doi:10.11852/zgetbjzz2024-1084

Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (6): 623-628.DOI: 10.11852/zgetbjzz2024-1084

• Original Articles • Previous Articles Next Articles

Correlation between feeding methods and gastrointestinal symptoms in 1-month-old infants

ZHANG Jiahui¹, ZHANG Simin¹, WANG Zhixu², YANG Nianhong³, Thomas Ludwig⁴, LUO Xiaoqin¹

1. School of Public Health, Xi′an Jiaotong University Health Science Center, Xi′an, Shaanxi 710061, China;
2. School of Public Health, Nanjing Medical University;
3. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;
4. Danone Open Science Research Center

Received:2024-09-09 Revised:2025-02-10 Online:2025-06-10 Published:2025-06-05
Contact: LUO Xiaoqin,E-mail:luoxiaoqin2012@mail.xjtu.edu.cn

喂养方式与1月龄婴儿胃肠道症状的关系研究

张佳慧¹, 张思敏¹, 汪之顼², 杨年红³, Thomas Ludwig⁴, 罗小琴¹

1.西安交通大学医学部公共卫生学院,陕西西安 710061;
2.南京医科大学公共卫生学院;
3.华中科技大学同济医学院公共卫生学院;
4.达能开放科研中心

通讯作者: 罗小琴,E-mail:luoxiaoqin2012@mail.xjtu.edu.cn
作者简介:张佳慧(2000—),女,硕士学位,主要从事母婴健康相关研究。
基金资助:
中国达能开放科学研究中心和荷兰达能纽迪西亚研究所资助(SBB20R&32016)

Abstract

Abstract: Objective To investigate the association between different feeding methods and infant gastrointestinal health, in order to provide evidence to promote exclusive breastfeeding during early infancy. Methods Participants were recruited from November 2021 to September 2022 in Nanjing, Chengdu, Xi′an, Wuhan, Guangzhou, and Qingdao.Infant gastrointestinal health was assessed using the Infant Gastrointestinal Symptom Questionnaire (IGSQ).Generalized linear models and Logistic regression analyses were employed to examine the relationship between feeding methods and IGSQ scores, as well as common gastrointestinal symptoms. Results A total of 765 mother-infant pairs were included.The median IGSQ scores were 21.00 (17.00, 25.00) for the exclusive direct breastfeeding group, 22.00 (18.00, 26.00) for the exclusive breastfeeding (direct + bottle-fed) group, and 22.00 (18.00, 27.00) for the mixed-feeding group.The average IGSQ score of infants in the mixed feeding was 1.106 points higher than that of the exclusive direct breastfeeding group (95%CI: 0.060 - 2.152, P=0.038).Compared with exclusive direct breastfeeding, mixed feeding was associated with a higher risk of constipation in infants(AOR=1.96, 95%CI: 1.198 - 3.202, P=0.007).The risk of dysphagia in infants in the exclusive breastfeeding (direct+bottle-fed)group and mixed feeding group was 2.14 (95%CI: 1.074 - 4.256, P=0.030) and 2.52 (95%CI: 1.371 - 4.637, P=0.003) times as high as that in the exclusive direct breastfeeding group, respectively.Additionally, exclusively breastfed infants exhibited fewer signs of irritability. Conclusions Exclusive direct breastfeeding in early infancy may help reduce gastrointestinal burden and negative emotional expressions in infants, demonstrating beneficial effects on gastrointestinal health.

Key words: gastrointestinal symptoms, feeding methods, emotion, infants

摘要： 目的探讨不同喂养方式与婴儿胃肠道健康之间的关系,为促进婴儿早期纯母乳喂养提供依据。方法 2021年11月—2022年9月在南京、成都、西安、武汉、广州和青岛地区招募受试者。运用婴儿胃肠道症状问卷(IGSQ)评估婴儿胃肠道健康状况。采用广义线性模型和Logistic回归分析探讨喂养方式与婴儿IGSQ评分和常见胃肠道症状之间的关系。结果研究纳入765对母婴,纯母乳亲喂组婴儿IGSQ评分中位数为21.00(17.00, 25.00),纯母乳亲喂+瓶喂组为22.00(18.00, 26.00),混合喂养组为22.00(18.00, 27.00),混合喂养组婴儿平均IGSQ分值较纯母乳亲喂组高1.106分(95%CI:0.060~2.154, P=0.038)。混合喂养组婴儿便秘发生风险高于纯母乳亲喂组(AOR=1.96, 95%CI: 1.198~3.202, P=0.007),纯母乳亲喂+瓶喂组婴儿和混合喂养组婴儿吞咽困难发生风险分别是纯母乳亲喂组的2.14倍(95%CI: 1.074~4.256, P=0.030)和2.52倍(95%CI: 1.371~4.637, P=0.003)。此外,纯母乳喂养婴儿烦躁情绪表达更少。结论早期纯母乳亲喂能够帮助减少婴儿胃肠道负担和消极情绪表达,对促进胃肠道健康具有积极意义。

关键词: 胃肠道症状, 喂养方式, 情绪, 婴儿

CLC Number:

R179

ZHANG Jiahui, ZHANG Simin, WANG Zhixu, YANG Nianhong, Thomas Ludwig, LUO Xiaoqin. Correlation between feeding methods and gastrointestinal symptoms in 1-month-old infants[J]. Chinese Journal of Child Health Care, 2025, 33(6): 623-628.

张佳慧, 张思敏, 汪之顼, 杨年红, Thomas Ludwig, 罗小琴. 喂养方式与1月龄婴儿胃肠道症状的关系研究[J]. 中国儿童保健杂志, 2025, 33(6): 623-628.

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Correlation between feeding methods and gastrointestinal symptoms in 1-month-old infants

喂养方式与1月龄婴儿胃肠道症状的关系研究

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