Multi-center survey on serum folic acid in preschool children in China

doi:10.11852/zgetbjzz2022-1527

Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (7): 713-717.DOI: 10.11852/zgetbjzz2022-1527

• Basic Experimental Articles • Previous Articles Next Articles

Multi-center survey on serum folic acid in preschool children in China

LIU Min¹, ZHANG Qian¹, YANG Ting¹, CHEN Jie¹, CHEN Li¹, DAI Ying¹, JIA Feiyong², WU Lijie³, HAO Yan⁴, LI Ling⁵, ZHANG Jie⁶, KE Xiaoyan⁷, YI Mingji⁸, HONG Qi⁹, CHEN Jinjin¹⁰, FANG Shuanfeng¹¹, WANG Yichao¹², WANG Qi¹³, JIN Chunhua¹⁴, LI Tingyu¹

1. Children′s Nutrition Laboratory of Children′s Hospital Affiliated to Chongqing Medical University, Chongqing Key Laboratory of Children′s Nutrition and Health, Key Laboratory of Children′s Developmental Diseases Research of Ministry of Education, National Children′s Health and Disease Clinical Medical Research Center, Chongqing 401331, China;
2. First Hospital of Jilin University;
3. Children′s Development Behavior Research Center of Harbin Medical University;
4. Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology;
5. Hainan Women and Children Medical Center;
6. Xi ′an Children′s Hospital;
7. Brain Hospital Affiliated to Nanjing Medical University;
8. Qingdao University Affiliated Hospital;
9. Shenzhen Baoan Maternal and Child Health Hospital;
10. Shanghai Children′s Hospital;
11. Henan Children′s Hospital;
12. Hunan Maternal and Child Health Hospital;
13. Deyang Maternal and Child Health Hospital;
14. Children′s Hospital Affiliated to Capital Institute of Pediatrics

Received:2022-12-22 Revised:2023-03-13 Online:2023-07-10 Published:2023-07-12
Contact: LI Tingyu, E-mail: tyli@vip.sina.com

全国多中心学龄前儿童血清叶酸现况调查

刘敏¹, 张倩¹, 杨亭¹, 陈洁¹, 陈立¹, 代英¹, 贾飞勇², 武丽杰³, 郝燕⁴, 李玲⁵, 张婕⁶, 柯晓燕⁷, 衣明纪⁸, 洪琦⁹, 陈津津¹⁰, 方拴锋¹¹, 王益超¹², 王琦¹³, 金春华¹⁴, 李廷玉¹

1.重庆医科大学附属儿童医院儿童营养研究室,儿童营养与健康重庆市重点实验室,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,重庆 401331;
2.吉林大学第一医院;
3.哈尔滨医科大学儿童发育行为研究中心;
4.华中科技大学同济医学院附属同济医院;
5.海南省妇女儿童医学中心;
6.西安市儿童医院;
7.南京医科大学附属脑科医院;
8.青岛大学附属医院;
9.深圳市宝安区妇幼保健院;
10.上海市儿童医院;
11.河南省儿童医院;
12.湖南省妇幼保健院;
13.德阳市妇幼保健院;
14.首都儿科研究所附属儿童医院

通讯作者: 李廷玉,E-mail: tyli@vip.sina.com
作者简介:刘敏(1993-),女,重庆人,在读专业型研究生,主要研究方向为儿童血清叶酸。
基金资助:
国家自然科学基金面上项目(81771223);科技基础资源调查专项(2017FY101100,子课题编号2017FY101103)

Abstract

Abstract: Objective To understand the situation of the serum folic acid level and folic acid deficiency in Chinese preschool children, and to compare them with the current reference range of serum folic acid provided by WHO and the United States US Centers for Disease Control and Prevention (CDC), so as to provide basis and suggestions for the establishment of the reference value of serum folic acid for Chinese preschool children. Methods From May 2018 to December 2019, children were recruited from 13 cities across five geographical regions in China, and finally a sample of 1 373 healthy children under 7 years old was obtained. Serum folic acid level was quantitatively determined by automatic chemiluminescence immunoassay (mindray, CL-1000i, China). Results The overall serum folic acid level was 12.46 (10.08~15.35)ng/mL, and the reference interval (P₅-P₉₅) ranged from 6.89 to 21.00ng/mL. Taking serum folic acid level <2ng/mL (CDC standard), ＜4ng/mL (WHO standard) and <6.89ng/mL(P₅ in this study) as the threshold values for serum folic acid deficiency, the number of folic acid deficiency in this population was 0, 3 (0.22%) and 66 (4.81%), respectively. The difference in serum folic acid level between different age groups was statistically significant (F=1.244, P<0.05). Serum folic acid level was negatively correlated with age (β=-0.998), and has no significant correlation with WAZ, HAZ and BMI. There was no statistical difference in serum folic acid level between boys and girls among children in different age groups (P＞0.05). Conclusion The determination of serum folic acid deficiency at a single threshold point is not applicable to preschool children, and the reference value of serum folic acid level should be set according to age.

Key words: preschool children, serum folic acid, China multi-center autism projiet

摘要： 目的了解中国学龄前儿童血清叶酸水平、叶酸缺乏情况,并与WHO及美国疾控中心(CDC)提供的血清叶酸参考值范围进行比较,为中国学龄前儿童血清叶酸参考值的制定提供依据及意见。方法 2018年5月—2019年12月跨越中国东南西北中5个地区的13个城市招募儿童,最终获得1 373例小于7岁儿童样本,采用全自动化学发光免疫分析法(Mindray,CL-1000i,China)定量测定血清叶酸水平。结果总体血清叶酸水平为12.46(10.08～15.35)ng/mL,参考区间(P₅～P₉₅)为6.89～21.00ng/mL,将CDC血清叶酸＜2ng/mL、WHO血清叶酸＜4ng/mL及本研究血清叶酸P₅所对应血清叶酸值6.89ng/mL分别作为血清叶酸缺乏临界值,本人群叶酸缺乏人数分别为0人、3人(0.22%)、66人(4.81%);不同年龄组间血清叶酸水平比较差异有统计学意义(F=1.244,P＜0.05)。血清叶酸与年龄呈负相关(β=-0.998),与WAZ、HAZ、BMIZ无相关关系。各年龄组不同性别血清叶酸水平比较差异无统计学意义(P＞0.05)。结论单个界值点判断血清叶酸缺乏不适用于学龄前儿童,其血清叶酸参考值需要按照年龄制定。

关键词: 学龄前儿童, 血清叶酸, 全国多中心研究

CLC Number:

R179

LIU Min, ZHANG Qian, YANG Ting, CHEN Jie, CHEN Li, DAI Ying, JIA Feiyong, WU Lijie, HAO Yan, LI Ling, ZHANG Jie, KE Xiaoyan, YI Mingji, HONG Qi, CHEN Jinjin, FANG Shuanfeng, WANG Yichao, WANG Qi, JIN Chunhua, LI Tingyu. Multi-center survey on serum folic acid in preschool children in China[J]. Chinese Journal of Child Health Care, 2023, 31(7): 713-717.

刘敏, 张倩, 杨亭, 陈洁, 陈立, 代英, 贾飞勇, 武丽杰, 郝燕, 李玲, 张婕, 柯晓燕, 衣明纪, 洪琦, 陈津津, 方拴锋, 王益超, 王琦, 金春华, 李廷玉. 全国多中心学龄前儿童血清叶酸现况调查[J]. 中国儿童保健杂志, 2023, 31(7): 713-717.

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Multi-center survey on serum folic acid in preschool children in China

全国多中心学龄前儿童血清叶酸现况调查

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