目的 探索肥胖儿童的血清鸢尾素水平和内分泌代谢指标的关系,为临床实践提供参考资料。方法 选取2022年5月—2023年5月临沂市人民医院门诊行健康查体的89名儿童,依据体质量指数(BMI)分为肥胖组48例和正常对照组41例,测量体量指标、检测血清鸢尾素及相关内分泌代谢参数。采用多元线性回归分析影响肥胖儿童血清鸢尾素水平的内分泌代谢指标的相关因素。结果 肥胖组儿童血清鸢尾素、游离三碘甲状腺原氨酸(FT3)、游离三碘甲状腺原氨酸/游离甲状腺素(FT3/FT4)、促甲状腺激素(TSH)、促肾上腺皮质激素(ACTH)、甘油三脂(TG)、C肽、胰岛素、胰岛素抵抗指数(HOMA-IR)均高于对照组(t/Z＝2.120、2.836、2.403、2.325、2.099、5.870、7.186、7.120、7.103),高密度脂蛋白(HDL-C)低于对照组(t＝4.084),差异均有统计学意义(P＜0.05)。肥胖儿童血清鸢尾素与TG呈正相关(r＝0.390,P＝0.006),与FT3呈负相关(r=-0.311,P=0.032)。多元线性回归分析发现FT3(β=-0.468)、TG(β=0.599)是肥胖儿童血清鸢尾素水平的主要影响因素(P<0.05)。结论 肥胖儿童血清鸢尾素水平高,与脂质代谢及甲状腺功能存在相关性。
Abstract
Objective To study the association of serum irisin level with endocrine and metabolic parameters in obese children,in order to provide reference for clinicd practice. Methods Data of 89 children treated in Linyi People's Hospital from May 2022 to May 2023 were retrospectively analyzed.According to body mass index (BMI), children were divided into obesity group (n=48) and normal control group (n=41).Multiple linear regression analysis was used to analyze the related factors of serum irisin and endocrine metabolism indexes. Results The levels of serum irisin, free triiodothyronine (FT3), free triiodothyronine/free thyroxine (FT3/FT4), thyroid stimulating hormone (TSH),adrenocoriticotropbic hormone(ACTH), triglyceride (TG), C-peptide, insulin, insulin resistance index (HOMA-IR)in obese children were significantly higher than those of the control group (t/Z=2.120, 2.836, 2.403, 2.325, 2.099, 5.870, 7.186, 7.120, 7.103, P<0.05), while high-density lipoproteinwas significantly lower than that in the control group (t=4.084, P<0.05).It was found that serum irisin level was positively correlated with TG (r=0.390, P=0.006) and negatively correlated with FT3 (r=-0.311, P=0.032).Multiple linear regression analysis showed that FT3 (β=-0.468) and TG (β=0.599) were the main factors influencing serum irisin levels in obese children. Conclusion Obese children have a high serum irisin level, and irisin is associated with lipid metabolism and thyroid function.
关键词
血清鸢尾素 /
甲状腺功能 /
肥胖儿童 /
糖脂代谢
Key words
serum irisin /
thyroid function /
obese children /
glucose and lipid metabolism
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参考文献
[1] Briganti SI, Gaspa G, Tabacco G, et al.Irisin as a regulator of bone and glucose metabolism[J].Minerva Endocrinol, 2018, 43(4): 489-500.
[2] Liu S, Cui F, Ning K, et al.Role of irisin in physiology and pathology[J].Front Endocrinol (Lausanne), 2022, 13: 962968.
[3] 李辉, 宗心南, 季成叶,等.中国2～18岁儿童青少年超重和肥胖筛查体重指数界值点的研究[J].中华流行病学杂志, 2010, 31(6): 616-620.
Li H, Zong XN, Ji CY, et al.A study on the cutoff pointsof body mass index for screening overweight and obesity in children and adolescents aged 2-18 in China[J].Chin J Epidemiol, 2010, 31(6): 616-620.(in Chinese)
[4] Luo Y, Qiao X, Ma Y, et al.Disordered metabolism in mice lacking irisin[J].Sci Rep, 2020, 10(1): 17368.
[5] De Meneck F, de Souza LV, Brioschi ML, et al.Emerging evidence for the opposite role of circulating irisin levels and brown adipose tissue activity measured by infrared thermography in anthropometric and metabolic profile during childhood[J].J Therm Biol, 2021, 99: 103010.
[6] De Meneck F, Victorino de Souza L, Oliveira V, et al.High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells[J].Nutr Metab Cardiovasc Dis, 2018, 28(7): 756-764.
[7] Dokumacioglu E, Iskender H, Sahin A, et al.Serum levels of nesfatin-1 and irisin in obese children[J].Eur Cytokine Netw, 2020, 31(1): 39-43.
[8] Shim YS, Kang MJ, Yang S, et al.Irisin is a biomarker for metabolic syndrome in prepubertal children[J].Endocr J, 2018, 65(1): 23-31.
[9] Elizondo-Montemayor L, Mendoza-Lara G, Gutierrez-DelBosque G, et al.Relationship of circulating irisin with body composition, physical activity, and cardiovascular and metabolic disorders in the pediatric population[J].Int J Mol Sci, 2018, 19(12).
[10] Maak S, Norheim F, Drevon CA, et al.Progress and challenges in the biology of FNDC5 and irisin[J].Endocr Rev, 2021, 42(4): 436-456.
[11] Witkowska-Sędek E, Kucharska A, Rumińska M, et al.Thyroid dysfunction in obese and overweight children[J].Endokrynol Pol, 2017, 68(1): 54-60.
[12] Song RH, Wang B, Yao QM, et al.The impact of obesity on thyroid autoimmunity and dysfunction: A systematic review and meta-analysis[J].Front Immunol, 2019, 10: 2349.
[13] Lu D, Yuan Z, Gao Y, et al.Central obesity is associated with variations in TSH and ACTH levels among euthyroid obese individuals[J].Int J Endocrinol, 2022, 2022: 3830380.
[14] de Oliveira M, Mathias LS, Rodrigues BM, et al.The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells[J].Mol Cell Endocrinol, 2020, 506: 110744.
[15] Sentis SC, Oelkrug R, Mittag J.Thyroid hormones in the regulation of brown adipose tissue thermogenesis[J].Endocr Connect, 2021, 10(2): 106-115.
[16] Leustean L, Preda C, Teodoriu L, et al.Role of Irisin in endocrine and metabolic disorders—possible new therapeutic agent?[J].Applied Sciences, 2021, 11(12): 5579.
[17] Tekin S, Erden Y, Ozyalin F, et al.Central irisin administration suppresses thyroid hormone production but increases energy consumption in rats[J].Neuroscience letters, 2018, 674: 136-141.
[18] Samy DM, Ismail CA, Nassra RA.Circulating irisin concentrations in rat models of thyroid dysfunction-effect of exercise[J].Metabolism, 2015, 64(7): 804-813.
基金
山东省医药卫生科技发展计划项目(202306010730)
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