关键词: 极低出生体重儿, 维生素D, 临床结局

Abstract: Objective To analyze the influence of serum 25-(OH) D level on the clinical outcomes of very low birth weight infants, in order to provide new orientation for the prevention and treatment of related disease in preterm infants. Methods From September 2019 and September 2020, a total of 105 very low birth weight infants hospitalized in Neonatal Intensive Care Unit (NICU) of Affiliated Hospital of Jining Medical College were selected as study subjects. According to the level of serum 25-(OH)D within 24 hours after birth, infants were divided into severe vitamin D deficiency group (group A), vitamin D deficiency group (group B) and control group. General characteristics, length of hospital stay, complications and clinical outcomes of infants in the three groups were compared. Results A total of 105 infants with very low birth weight were included.The mean serum 25-(OH)D was (14.33±3.60)ng/ml at birth.The incidence of vitamin D deficiency was 79.1%.The serum 25-(OH)D level of infants born in summer and autumn was significantly higher than that in winter and spring (t=2.71,P=0.01).The birth weight of the infants for group A and group B was lower than those of the control group(F=0.86,P<0.01;Z score: F=5.43,P=0.01).1- minute Apgar score of the infants for group A and group B were lower than those of the control group(F=9.05,P<0.01).The older the mother was, the higher the incidence of vitamin D deficiency was, and the difference between the three groups was statistically significant (F=8.40,P<0.01).The length of hospital stay, duration of oxygen use, duration of ventilation in infants with vitamin D deficiency were significantly higher than those in the control group, with statistically significant differences among the three groups (F=19.65,7.45,15.97,4.87,P<0.05).The incidence of RDS、BPD and ROP in infants with vitamin D deficiency was higher than control group, the difference between the three groups was statistically significant (χ²=17.37,P<0.05).Logistic regression analysis showed that vitamin D deficiency at birth was a risk factor for RDS(OR=6.604,95%CI:1.828 - 23.862,P=0.004)、BPD(OR=8.199,95%CI:1.428 - 47.067,P=0.018). Conclusions Serum 25-(OH) D deficiency is prevalent in very low birth weight infants. For very low birth weight infants, low serum 25-(OH)D level may increase the duration of oxygen therapy and respiratory support, increase the incidence of BPD, RDS and ROP, and prolong the length of hospital stay.

Key words: very low birth weight infants, vitamin D deficiency, clinical outcomes