关键词: 可溶性髓细胞表达触发受体1, 肺炎, 前降钙素, C反应蛋白

Abstract: Objective To discuss the diagnostic value of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in identifying pediatric community-acquired pneumonia(CAP). Methods 60 cases of hospitalized children with pneumonia were selected(including 31 cases of bacterial pneumonia and 29 cases of non bacterial pneumonia),healthy children were recruited as controls.The serum level of sTREM-1,procalcitonin (PCT),C-reactive protein (CRP) and white blood cell count (WBC) count were detected and the changes of sTREM-1,PCT and CRP before and after the treatment in children with bacterial pneumonia were compared.The levels of sTREM-1,PCT,CRP were compared between severe pneumonia and non severe pneumonia. Results 1)sTREM-1 level in plasma of bacterial pneumonia group was higher than that in non-bacterial pneumonia group and normal control group [(36.36±8.88)μg/L vs.(16.86±1.83)μg/L,(16.27±1.97)μg/L (P<0.05)].There was no statistical significance between non-bacterial pneumonia group and normal control group (P>0.05).2)sTREM-1 level in plasma of severe pneumonia group was higher than that in non-severe pneumonia group [(61.18±13.72)μg/L vs.(33.97±9.21)μg/L(P<0.05)],sTREM-1 level in plasma of non-severe pneumonia group was higher than that in normal control group [(33.97±9.21)μg/L vs.(16.27±1.97)μg/L (P<0.05)].3) The levels of PCT,CRP and WBC in plasma of bacterial pneumonia group were higher than those in non-bacterial pneumonia group and normal control group (P<0.05);the levels of PCT,CRP and WBC in plasma of severe pneumonia group were higher than those in non-severe pneumonia group (P<0.05).4) After treatment,the level of sTREM-1 showed a continuous decline in bacterial pneumonia group [(36.36±8.88)μg/L vs (27.34±6.48)μg/L,(16.38±4.20)μg/L],the difference was significant (P<0.05).But the early decline in PCT and CRP were not obvious (third days vs.first days),there were no significant difference (P>0.05). Conclusion sTREM-1 is an important index in earlier period identification of bacterial pneumonia,it is of great meaning to guide the rational use of antibiotics,assess the condition and judge the curative effect.

Key words: soluble triggering receptor expressed on myeloid cells-1, pneumonia, procalcitonin, C-reactive protein