辅助生殖技术受孕的双胎早产儿出生结局与早期神经行为发育的队列研究

doi:10.11852/zgetbjzz2024-1446

中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (12): 1381-1385.DOI: 10.11852/zgetbjzz2024-1446

辅助生殖技术受孕的双胎早产儿出生结局与早期神经行为发育的队列研究

许雨虹^1*, 高雪婷^2*, 张慧平³, 白枫², 王端³, 何玉莹⁴, 卜婧愉^5,6, 张旖¹, 陈艳妮³

1.西安交通大学医学部,陕西西安 710061;
2.西北妇女儿童医院儿童保健科,陕西西安 710061;
3.西安市儿童医院儿童保健科;
4.西安市妇幼保健院;
5.西安交通大学生命科学与技术学院,生物医学信息工程教育部重点实验室,健康与康复科学研究所;
6.空军军医大学第二附属医院唐都医院儿科

收稿日期:2024-12-09 修回日期:2025-04-25 发布日期:2025-12-02 出版日期:2025-12-10
通讯作者: 陈艳妮,E-mail:chenyannichil@163.com
作者简介:许雨虹(1994—),女,硕士研究生,主要研究方向为试管早产儿发育行为; 高雪婷(1968—),女,本科学历,主要研究方向为儿童保健学。
基金资助:
国家自然科学基金(81371900);陕西省重点研发计划(2020GXLH-Y-013,2021SF-194);陕西省科学技术研究发展计划(213ST2-09);陕西省自然科学基础研究计划(2022JQ-979);西安市科技计划项目[20YXYJ0006(4)];陕西中医药大学中西医结合防治脑发育障碍性疾病创新团队(2019-YL07);上海申康医院发展中心临床三年行动计划资助(SHDC2020CR1047B)

Cohort study of birth outcomes and early neurobehavioral developmentin twins conceived via assisted reproductive technology

XU Yuhong^1*, GAO Xueting^2*, ZHANG Huiping³, BAI Feng², WANG Duan³, HE Yuying⁴,BU Jingyu^5,6, ZHANG Yi¹, CHEN Yanni³

1. Xi′an Jiaotong University Medical Science Center, Xi′an, Shaanxi 710061, China;
2. Department of Child Health Care, Northwest Women′s and Children′s Hospital, Xi′an, Shaanxi 710061,China;
3. Department of Child Health Care, Xi′an Children′s Hospital;
4. Xi′an Maternity and Child Healthcare Hospital;
5. School of Life Science and Technology, Xi′an Jiaotong University,The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science;
6. Department of Pediatrics, Tangdu Hospital of Air Force Medical University

Received:2024-12-09 Revised:2025-04-25 Online:2025-12-10 Published:2025-12-02
Contact: CHEN Yanni,E-mail:chenyannichil@163.com

摘要/Abstract

摘要： 目的分析辅助生殖技术(ART)受孕与自然受孕双胎早产儿的出生结局差异,并评估其早期神经行为发育特征,为ART受孕婴儿的健康管理提供合理建议。方法采用回顾性队列研究方法选取2017年1月—2022年1月在西安市儿童医院儿童保健科门诊定期体检的双胎早产儿,共147对(n=294例)。根据不同受孕方式分为两组:ART受孕双胎早产儿78对为观察组(n=156例)和自然受孕双胎早产儿69对为对照组(n=138例)。收集两组孕产妇妊娠期疾病、双胎早产儿生后临床疾病等资料,两组早产儿均在矫正胎龄生后6月龄和12月龄时行Gesell发育行为评估。结果两组孕产妇妊娠期疾病发生率差异无统计学意义(P＞0.05)。观察组早产儿先天性心脏病发生率高于对照组,差异有统计学意义(χ²=12.05, P＜0.01)。两组婴儿矫正胎龄生后6月龄、12月龄时行Gesell发育行为评估结果差异均无统计学意义(P＞0.05)。结论 ART受孕的双胎早产儿患常见先天性心脏病风险更高,未发现复杂危重型先天性心脏病。两组双胎早产儿早期神经行为发育无显著差异,ART并未增加早产儿神经发育异常的风险。

关键词: 辅助生殖技术, 双胎早产儿, 出生结局, 神经行为发育

Abstract: Objective To compare birth outcomes and early neurobehavioral development between preterm twins conceived via assisted reproductive technology (ART) and those conceived naturally, in order to provide evidence-based recommendations for the health management of in vitro fertilization (IVF) infants. Methods This retrospective cohort study included 147 twin pairs (n=294) of preterm infants who underwent regular health examinations at the Child Health Clinic of Xi′an Children′s Hospital between January 2017 and January 2022.Participants were divided into two groups: 78 ART-conceived twin pairs (observation group, n=156) and 69 naturally conceived twin pairs (control group, n=138).Data on maternal gestational complications and neonatal clinical conditions were collected.Neurodevelopmental outcomes were assessed using the Gesell Developmental Schedules (GDS) at corrected ages of 6 and 12 months. Results No significant differences were observed in the incidence of maternal gestational complications between the two groups (P>0.05).The observation group exhibited a higher prevalence of congenital heart disease (CHD) compared to the control group (χ²=12.05, P < 0.05).However, no significant differences were found in GDS scores at 6 or 12 months of corrected age (P>0.05). Conclusions ART-conceived preterm twins have an increased risk of common CHD, but no cases of severe or complex CHD are identified.Early neurobehavioral development do not differ significantly between ART and naturally conceived preterm twins, suggesting that ART does not elevate the risk of neurodevelopmental abnormalities in this population.

Key words: assisted reproductive technology, twin premature infants, birth outcome, neurobehavioral development

中图分类号:

R179

许雨虹, 高雪婷, 张慧平, 白枫, 王端, 何玉莹, 卜婧愉, 张旖, 陈艳妮. 辅助生殖技术受孕的双胎早产儿出生结局与早期神经行为发育的队列研究[J]. 中国儿童保健杂志, 2025, 33(12): 1381-1385.

XU Yuhong, GAO Xueting, ZHANG Huiping, BAI Feng, WANG Duan, HE Yuying, BU Jingyu, ZHANG Yi, CHEN Yanni. Cohort study of birth outcomes and early neurobehavioral developmentin twins conceived via assisted reproductive technology[J]. Chinese Journal of Child Health Care, 2025, 33(12): 1381-1385.

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辅助生殖技术受孕的双胎早产儿出生结局与早期神经行为发育的队列研究

Cohort study of birth outcomes and early neurobehavioral developmentin twins conceived via assisted reproductive technology

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