围孕期阴道炎、牙周病对婴儿过敏性疾病影响的出生队列研究

doi:10.11852/zgetbjzz2024-1094

摘要/Abstract

摘要： 目的分析母亲围孕期阴道炎、牙周病和婴儿1岁内过敏性疾病症状的关联。方法 2015年6月—2016年6月,于马鞍山市妇幼保健院建立母婴健康队列。收集父母及幼儿一般人口学信息、围孕期阴道炎、牙周病情况等资料,采用二分类logistic回归分析围孕期牙周病、阴道炎对婴儿1岁内过敏性疾病症状的影响。结果共纳入1 760对母婴。孕妇孕前3个月、孕早期和孕中期阴道炎发生率分别为8.6%、2.6%和3.2%,孕妇前3个月、孕早期和孕中期牙周病发生率44.2%、39.3%和46.9%。婴儿1岁内过敏性疾病发病率为25.6%。调整混杂因素后,发现孕前3个月患阴道炎(OR=1.69,95%CI:1.18～2.43)及孕中期患牙周病(OR=1.36,95%CI:1.09～1.70)是婴儿过敏性疾病症状发生的危险因素。结论母亲围孕期牙周病、阴道炎是婴儿发生过敏性疾病症状的危险因素,建议孕龄女性在备孕期间尽量先治疗好牙周病和阴道炎。

关键词: 围孕期, 牙周病, 阴道炎, 过敏性疾病, 队列研究

Abstract: Objective To analyze the association between maternal perinatal vaginitis, periodontal disease, and the occurrence of allergic disease symptoms in infants within the first year of life. Methods A maternal-infant health cohort was established at Ma'anshan Maternal and Child Health Care Hospital from June 2015 to June 2016. General demographic information of parents and infants, as well as data on perinatal vaginitis and periodontal disease, were collected. Binary logistic regression analysis was used to evaluate the impact of perinatal periodontal disease and vaginitis on the occurrence of allergic disease symptoms in infants within the first year of life. Results A total of 1 760 mother-infant pairs were included in this study. The prevalence rates of vaginitis during the three months before pregnancy, first trimester, and second trimester were 8.6%, 2.6%, and 3.2%, respectively. The prevalence rates of periodontal disease during the three months before pregnancy, first trimester, and second trimester were 44.2%, 39.3%, and 46.9%, respectively. The incidence of allergic disease symptoms in infants within the first year of life was 25.6%. After adjusting for confounding factors, vaginitis during the three months before pregnancy (OR= 1.69, 95%CI: 1.18 - 2.43) and periodontal disease during the second trimester (OR= 1.36, 95% CI: 1.09 - 1.70) were identified as risk factors for the occurrence of allergic disease symptoms in infants. Conclusions Maternal prenatal vaginitis and periodontal disease are risk factors for the development of allergic disease symptoms in infants. It is recommended that women of childbearing age receive treatment for periodontal disease and vaginitis before conception.

Key words: perinatal pregnancy, periodontal disease, vaginitis, allergic diseases, cohort study

中图分类号:

R722.6

尹小刚, 陈茂林, 曹慧, 高国朋, 谢亮亮, 陶芳标, 严双琴. 围孕期阴道炎、牙周病对婴儿过敏性疾病影响的出生队列研究[J]. 中国儿童保健杂志, 2026, 34(1): 71-75.

YIN Xiaogang, CHEN Maolin, CAO Hui, GAO Guopeng, XIE Liangliang, TAO Fangbiao YAN Shuangqin. Cohort study on the impact of maternal perinatal vaginitis and periodontal disease on allergic diseases in infants[J]. Chinese Journal of Child Health Care, 2026, 34(1): 71-75.

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