关键词: 早产儿, 新生儿暂时性呼吸增快, 持续气道正压通气, 呼吸窘迫综合征

Abstract: Objective To investigate the clinical efficacy of nasal continuous positive airway pressure (CPAP) in the treatment of middle and late preterm infants with transient tachypnea of the newborn (TTN),in order to provide evidence for treatment of TTN in children. Methods A total of 41 preterm infants with TTN at gestational age of 32 to 37 weeks were enrolled in this study in the First Affiliated Hospital of Hainan Medical College from March 2018 to February 2019,and were randomly divided into observation group(n=20) and control group(n=21).Both of them took emergency pulmonary ultrasound and chest X-ray,and were treated with conventional therapy.Additionally,the observation group was given nasal CPAP (FiO₂ 21%,PEEP 4~6 cmH₂O),while the control group breathed air in the normal atmospheric pressure.The TTN clinical score,respiratory rate,percutaneous blood oxygen saturation,the hospitalization time,whether to start the emergency plan and complication at admission and after treatment in 30 minutes were compared between the two groups. Results There were significant differences on the total effective rate of treatment,the probability of starting emergency plan and TTN clinical score after 30 minutes of treatment between the observation group and the control group(χ²=5.236,8.912,t=-3.042,P<0.05).And there were significant differences on respiratory frequency,TTN clinical score and percutaneous oxygen saturation in the observation group and the control group (t=5.145, 3.608, 7.664,5.535,-4.260,-4.891,P<0.05).Also,significant difference was found on the incidence of complications between the two groups (P<0.05).The accuracy of ultrasonic diagnosis of TTN was 97.56%. Conclusion s Early application of CPAP (FiO₂ 21%,PEEP 4-6 cmH₂O) can significantly improve the symptoms of dyspnea in TTN premature infants and reduce the probability of oxygen use.The accuracy of ultrasonic diagnosis of TTN is high,ultrasonic testing is safe,radiation-free and easy to operate,which is worthy of promotion and application in NICU.

Key words: preterm infant, transient tachypnea of the newborn, continuous positive airway pressure, respiratory distress syndrome