Objective To investigate the efficacy of individualized vitamin D supplementation in very preterm infants, in order to provide reference for optimizing the vitamin D supplementation strategy for very preterm infants. Methods A total of 106 very preterm infants hospitalized in NICU from July 2021 to July 2022 were selected into this study, and were randomly divided into observation group (n=47) and control group (n=59). Infants in both groups took vitamin D supplementation from the 7th day after birth. In the observation group, infants received daily vitamin D supplementatation,and the dose was based on their serum 25-hydroxy vitamin D[25-(OH)D] level:800U was taken orally for the infants with sufficient vitamin D; for infants with vitamin D insufficiency, oral vitamin D supplementation was increased to 1 400U; for infants with vitamin D deficiency, oral vitamin D supplementation was increased to 1 800U; for infants with excessive vitamin D, oral vitamin D dose was reduced to 400U; for infants with vitamin D potential poisoning and poisoning, vitamin D supplementation would be discontinued. In the control group, infants were routinely supplemented with 800U vitamin D. Serum levels of 25-(OH)D, the incidence of vitamin D deficiency/insufficiency, and the occurrence of vitamin D overdose or poisoning were compared between the two groups within 48 hours, 4 weeks and 8 weeks after birth. Results The incidence of vitamin D deficiency and insufficiency in 106 very preterm infants within 48 hours after birth was 81.1% and 9.43%, respectively. There was no significant difference in serum 25-(OH)D level and incidence of vitamin D deficiency/insufficiency between the two groups within 48h after birth (P>0.05). The level of serum 25-(OH) D in the observation group was significantly higher than that in the control group at 4 and 8 weeks after birth (t=3.84, 5.94, P<0.05), and the incidence rate of vitamin D deficiency was significantly lower than that in the control group (χ2=11.02, 18.32, P<0.05). Conclusion Compared with the routine supplementation of 800U vitamin D, individualized vitamin D supplementation can significantly increase serum 25-(OH)D level at 4 and 8 weeks after birth and reduce the incidence of vitamin D deficiency in very preterm infants.
Key words
individualized /
vitamin D supplementation /
25-hydroxyvitamin D /
very preterm infants
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