Objective To compare the curative effect of sublingual immunotherapy (SLIT) with standardized dermatophagoides farina drops in monosensitized and polysensitized children with allergic. Methods A total of 150 pediatric allergic rhinitis patients were enrolled as desensitization group and were allocated into monosensitized group (61 cases) and polysensitized group (89 cases) according to the number of coexisting allergens.Meanwhile 32 allergic rhinitis children treated by pharmacotherapy during the same period were collected as control group.The symptom scores (TNSS),drug scores (TMS) and visual analogue scale(VAS) were assessed at the beginning,6 months,1 year and 2 years of the treatment. Results The scores of TNSS and VAS in desensitization were slightly higher than those in the control after 6 months treatment,but without difference at 1 year and 2 years;The score of TMS had significant improvement in desensitization compared with the corresponding points in control.All the parameters in monosensitized group were equivalent with polysensitizend group,except the score of TMS was slightly lower than the polysensitizend group at 6 months. Conclusions Dust mites under the SLIT can significantly improve nasal symptoms of the monoallergen sensitized and polyallergen sensitized allergic children,reduce the symptomatic drug use,and two groups have similar curative effects.The rise of dust mites specific IgG₄ can be used as immunotherapy effective predictors.