Abstract: Objective To study the effect of the creatine phosphate in the treatment of severe neonatal asphyxia with myocardial damage. Methods A total of 68 cases of neonatal asphyxia newborns with severe myocardial damage were randomly divided into treatment group and the control group,the control group were treated with conventional treatment,and the treatment group were treated by creatine phosphate except conventional therapy.After treatment for 7 d,the myocardial enzymes changes were compared before and after treatment of the two groups of newborns,and to evaluate the therapeutic effect of the two groups of newborns. Results With creatine phosphate treatment,the therapeutic effect of the treatment group (79.41%) was significantly better than the control group (50%),and the treatment group's creatine kinase (CK:121.2±64.3),creatine kinase co-workers enzyme (CK-MB:22.4±11.3),lactate dehydrogenase(LDH:102.2±45.3),hydroxybutyrate dehydrogenase (HBDH:146.2±102.4),aspartate aminotransferase (AST:30.2±10.2) were less than control group. Conclusion In the treatment of severe neonatal asphyxia with myocardial damage,basic conventional treatment and phosphocreatine help improve the therapeutic effect,reduce the level of myocardial enzymes as soon as possible and worthy of clinical application.

Key words: phosphocreatine, neonatal asphyxia, myocardial damage

摘要： 目的 研究磷酸肌酸在治疗新生儿重度窒息心肌损害的临床效果,为重度窒息心肌损害的临床治疗提供参考。方法 将68例新生儿窒息伴重度心肌损害的新生儿随机分为治疗组及对照组,对照组采用常规治疗,治疗组在常规治疗的基础上加用磷酸肌酸治疗,疗程为7 d。比较两组新生儿治疗前后心肌酶谱的变化,并评价两组新生儿的治疗效果。结果 用磷酸肌酸治疗后,治疗组的效果(79.41%)明显优于对照组(50.0%),并且治疗组的磷酸肌酸激酶(121.2±64.3)、磷酸肌酸激酶同工酶(22.4±11.3)、乳酸脱氢酶(102.2±45.3)、羟丁酸脱氢酶(146.2±102.4)、谷草转氨酶(30.2±10.2)等均明显小于对照组,差异有统计学意义(P<0.05)。结论 在重度的新生儿窒息伴心肌损害的治疗中,常规治疗的基础上加用磷酸肌酸有助于提高治疗效果,有利于降低心肌酶谱水平。

关键词: 磷酸肌酸, 新生儿窒息, 心肌损害