Objective To observate the effects of salbutamol and ipratropium for preterm children of oxygenation. Methods A total of 112 cases of premature children were randomly divided into treatment group and control group, treatment group were given salbutamol and ipratropium bromide inhalation after admission on the basis of conventional therapy;Control group received conventional therapy only. Results Treatment group had dyspnea, hypoxemia, peripheral oxygen, apnea, only oxygen fell, the difference was not statistically significant compared with control group(P>0.05);dyspnea relief time, time to correct hypoxemia, peripheral oxygen time, apnea relief time, pure oxygen saturation fell remission time, which occurred in the treatment group compared with the control group, the differences were statistically significant(P<0.05).The signs and symptoms remission of treatment group were shorter than those of the control group. Conclusions Salbutamol and ipratropium bromide treatment of respiratory disease in preterm children, could not reduce their dyspnea, hypoxemia, apnea and other signs and symptoms.Peripheral oxygen can not be avoided, but it can improve symptoms and shorten the oxygen time, and also shorten the course.