Objective To study the changes of serum insulin-like growth factor-1(IGF-1),thyroid stimulating hormone(TSH) and free thyroxine(FT4) in children with congenital hypothyroidism(CH) by levothyroxine(L-T4) substitution therapy,and to analyse the effects on physical growth in these children. Methods IGF-I,TSH and FT4 were detected by chemiluminescence method which were collected from 27 untreated neonatus with CH,21 children with CH after therapy,30 healthy neonatus and 30 healthy children(as controls).Body weight (BW) and body length (BL) of each groups were measured. Results The levels of serum IGF-1,TSH and FT4 in neonatus with CH were significantly lower than those in healthy neonatus (P<0.05) while there were not differ between healthy children and children with CH after therapy (P>0.05).TSH,FT4,BW and BL had no correlations with IGF-1.BW and BL had inverse correlations with TSH while direct correlations with FT4 in neonatus with CH. Conclusions Physical growth of children with CH in fetal period may be affected by TSH and FT4.The normal levels of TSH,FT4 and IGF-1 may be possible factors for normal growth of children with CH.
Key words
congenital hypothyroidism /
insulin-like growth factor-1 /
physical development
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