Objective To investigate the levels of monocyte chemoattractant protein 4 (MCP-4),macrophage derived chemokine (MDC),cysteinyl leukotrienes (CysLTs) and eosinophils (EOS) in peripheral blood of children with asthma,in order to understand their roles in the pathogenesis of asthma and clinical significances. Methods Serum levels of MCP-4,MDC,CysLTs and EOS in 35 children with asthma exacerbation (asthma exacerbation group),32 children with asthma convalescence (asthma convalescence group),32 children with pneumonia (pneumonia group) and 25 health children (control group) were measured by enzyme linked immunosorbent assay (ELISA) and blood cells analyzer respectively,data were analysed. Results Serum levels of MCP-4,MDC,CysLTs and EOS in asthma exacerbation group were significantly higher than those in asthma convalescence group,pneumonia group and control group (P<0.05).The level of EOS was higher in asthma convalescence group than that in pneumonia group and control group (P<0.05).The levels of MCP-4,MDC,CysLTs in asthma convalescence group were higher than those in control group (P<0.05),but there were no significant differences compared with pneumonia group (P>0.05).The levels of MCP-4,MDC,CysLTs and EOS were associated with the severity of the disease,and there were positive correlations between them. Conclusions MCP-4,MDC and CysLTs are all involved in pathogenesis of asthma in children,and related to the severity of asthma,so their serum levels and counts can be used for diagnosis and evaluation of severity of asthma in children,and it is of great value to clinical treatment;Chronic inflammation still exists in convalescence phases of asthma.
Key words
childhood asthma /
monocyte chemoattractant protein 4 /
macrophage derived chemokine /
cysteinyl leukotrienes /
eosinophils
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