Objective To investigate the influence of infants caress on intellectual development of premature infants and to provide the basis for comprehensive intervention of premature infants. Methods The study group consisted of 30 premature infants who persisted in normative infants caress.Control group consisted of 33 premature infants who had the similar background information with the study group and didn't persist in infants caress.Data were selected from the children's health care system in our department from January 2008 to December 2009.The longitudinal study was used to analyze the data.Utilize Beijing children mental development scales were used to dynamic evaluation the intellectual developments of the two groups. Results When corrective months were six months,there were no significant differences between two groups in two parts of DQ include gross motor and adaptation (P>0.05).However,the DQ values of sample group include fine motor,language,social behavior were higher than those of reference group.The differences had statistical significance (P<0.01).When corrective months was one year,there were no significant differences (P>0.05) between two groups in gross motor.However,the DQ values of sample group include adaptation,fine motor,language,social behavior were higher than those of reference group.The differences had statistical significance (P<0.01).When corrective months were two years,the values of five parts of DQ in sample group were all higher than those of reference group,especially,in parts of fine motor,language,social behavior.The difference had statistical significance (P<0.01). Conclusion Adhering to the normative infants caress on the early stage can improve premature intelligence development.