Objective To explore the relationship between children with attention deficit hyperactivity disorder (ADHD) and their blood lead,zinc and ferrum levels. Method Blood lead,zinc and ferrum levels of 70 ADHD children and 60 healthy controls were determined by atomic absorption spectrometry. Results The blood zinc and ferrum levels [(74.39±10.71)μmol/L,(8.52±0.58)mmol/L] were lower in ADHD children,than those in health controls [(80.60±9.07)μmol/L,(8.76±0.51)mmol/L,t=3.538 or 2.536,P<0.01 or <0.05].The blood lead level [(57.3±20.9)μg/L] was higher in ADHD children than that in health controls [(45.9±17.4)μg/L,t=3.357,P<0.01]. Conclusion Blood lead is high and zinc and ferrum is deficient in some ADHD children,which should be determined routinely and retrieved as soon as possible.
Key words
attention deficit hyperactivity disorder /
blood lead /
blood zinc /
blood ferrum /
children
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References
[1] Blomqvist M,Holmbereg K,Lindblad F,et al.Salivary cortisol levels and dental anxiety in children with attention deficit hyperactivity disorder[J].Eur J Oral Sci,2007,115(1):1-6.
[2] Rajan P,Kelsey KT,Schwartz JD,et al.Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burdenon cognitive function:The VA normative aging study[J].J Occup Eneiron Med,2008,50(9):1053-1061.
[3] Do Cunha C,Wietzikoski S,Wietzikoski EC,et al.Evidence for the substanctia nigrapars compacta as an essential component of a memory system independent of the hippocampal memory system[J].Neurobiol Learn Mem,2003,79:236-242.
[4] Volkow ND,Wang GJ,Newcorn J,et al.Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder[J].Arch Gen Psychiatry,2007,64(8):932-940.
[5] 辛晓昱,吴媛,冀永娟,等.注意缺陷多动障碍与儿童血铅水平的关系研究[J].中国儿童保健杂志,2011,19(5):465-467.
[6] Nigg JT,Knottnerus GM,Martel MM,et al.Low blood lead levels associated with clinically diagnosed attention-deficit/hyperactivity disorder and mediated by weak cognitive control[J].Biol Psychiatry,2008,63(3):325-331.
[7] Arnold LE,Bozzolo H,Hollway J,et al.Serum zinc correlates with parent-and teacher-rated inattention in children with attention-deficit/hyperactivity disorder[J].Child Adolesc Psychopharmacol,2005,15(4):628-636.
[8] Penland J.Behavioral data and methodological issues in studies of zinc nutrition in humans[J].J Nutr,2000,130:361-364.
[9] Oner O,Alkar OY,Oner P.Relation of ferritin levels with symp-tom ratings and cognitive performance in children with attention deficit-hyperactivity disorder[J].Pediatr Int,2008,50(1):40-44.
[10] Grantham-McGregor S,Ani C.A review of studies on the effect of iron deficiency on cognitive development in children[J].J Nutr,2001,131(2S-2):649-666.
[11] 谭利娜,卫海燕,张耀东,等.血清铁蛋白与儿童注意缺陷多动障碍关系的Meta分析[J].中国当代儿科杂志,2011,13(9):722-724.
【作者简介】 牟文凤(1978-),女,山东人,检验技师,硕士学位,主要从事微量元素和免疫方面的检验工作。