Impact of pyrethroid pesticides exposure on development of one-year old infants

ZHENG Ming-lan; QI Xiao-juan; WU Chun-hua; WANG Guo-quan; LU Da-sheng; CHANG Xiu-li; ZHOU Zhi-jun

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Chinese Journal of Child Health Care ›› 2012, Vol. 20 ›› Issue (5) : 409-412.

Impact of pyrethroid pesticides exposure on development of one-year old infants

ZHENG Ming-lan¹,QI Xiao-juan¹,WU Chun-hua¹,WANG Guo-quan²,LU Da-sheng²,CHANG Xiu-li¹,ZHOU Zhi-jun¹

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Abstract

【Objective 】 To examine associations between pyrethroid pesticides exposure and development in one-year infants. 【Methods】 449 one-year old infants in a county of Jiangsu Province were studied.Their spot urine were collected and pyrethroid pesticides exposure was assessed by measuring pyrethroid metabolites (cis-Cl₂CA,trans-Cl₂CA and 3-PBA).The Physical examination and the DST Scale were done and their relationship with pesticides exposure was evaluated. 【Results】 Pyrethroid metabolites (cis-Cl₂CA,trans-Cl₂CA and 3-PBA) were found among 70.4%,97.6% and 84.2% of these infants,respectively.The weight and the chest circumference among different pyrethroid metabolites levels was significiantly different,but not the body length,the head circumference and the development quotient.The pyrethroid metabolites level was associated with a decrement in weight by using multiple liner analysis. 【Conclusion】 Our findings suggest that exposure to pyrethroid negatively impacts on the weight of one-year infants.

Key words

pyrethroid pesticides / infants / growth and development

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ZHENG Ming-lan,QI Xiao-juan,WU Chun-hua,WANG Guo-quan,LU Da-sheng,CHANG Xiu-li,ZHOU Zhi-jun. Impact of pyrethroid pesticides exposure on development of one-year old infants[J]. Chinese Journal of Child Health Care. 2012, 20(5): 409-412

References

[1] Meeker JD,Barr DB,Hauser R.Pyrethroid insecticide metabolites are associated with serum hormone levels in adult men[J].Reprod Toxicol,2009,27(2):155-160.
[2] Famtma M,Denerdash El.Lipid peroxidation,oxidative stress and acetylcholinesterase in rat brain exposed to organophosphate and pyrethroid insecticides[J].Food Chem Toxicol,2011,49(6):1346-1352.
[3] Demiccoa,Ooper KR,Richardson JR,et al.Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos[J].Toxicol Sci,2010,113(1):177-186.
[4] Shafer TJ,Meyer DA,Croffton KM.Developmental neurotoxicity of pyrethroid insecticides:critical review and future research needs[J].Environ Health Perspect,2005,113(2):123-136.
[5] 郑慕时,冯玲英,刘湘云.0~6 岁发育筛查测验实用手册[M].2007:1-55.
[6] 卢大胜,金玉娥,周志俊,等.尿中拟除虫菊酯类农药代谢物GC-MS测定方法研究[J].卫生研究,2011,40(3):371-374.
[7] Heudorf U,Butte W,Schulz C,et al.Reference values for metabolites of pyrethroid and organophosphorous insecticides in urine for human biomonitoring in environmental medicine[J].Int J Hyg Environ Health,2006,209:293-299.
[8] Tulve NS,Jones PA,Nishioka MG,et al.Pesticide measurements from the first national environmental health survey of child care centers using a multi-residue GC/MS analysis method[J].Environ Sci Technol,2006,40(20):6269-6274.
[9] Bradman A,Whitaker D,Quiros L,Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley,CA[J].J Expo Sci Environ Epidemiol,2007,17(4):331-349.
[10] Naeher LP,Tulve NS,Egeghy PP,et al.Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city[J].Sci Total Environ,2010,408(5):1145-1153.
[11] Schulz C,Angerer J,Ewers U,et al.Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German environmental survey on children 2003~2006 (GerES IV)[J].Int J Hyg Environ Health,2009,212(6):637-647.
[12] Egeghy PP,Cohen Hubal EA,Tulve NS,et al.Review of pesticide urinary biomarker measurements from selected US EPA children's observational exposure studies[J].Int J Environ Res Public Health,2011,8(5):1727-1754.
[13] Couture C,Fortin MC,Carrier G,et al.Assessment of exposure to pyrethroids and pyrethrins in a rural population of the Montérégie area,Quebec,Canada[J].J Occup Environ Hyg,2009,6(6):341-352.
[14] Young JG,Eskenazi B,Gladstone EA,et al.Association between in utero organophos- phate pesticide exposure and abnormal reflexes in neonates[J].NeuroToxicology,2005,26:199-209.
[15] Wolff MS,Engel S,Berkowitz G,et al.Prenatal pesticide and PCB exposures and birth outcomes[J].Pediatr Res,2007,61:243-250.
[16] Horton MK,Rundle A,Camann DE,et al.Impact of prenatal exposure to piperonyl butoxide and permethrin on 36-month neurodevelopment[J].Pediatrics,2011,127:699-706.
[17] 卫生部妇幼保健与社区卫生司.中国7岁以下儿童生长发育参照标准[S].2009.