Study on FUT2 gene polymorphism and the effect on breast-fed infants&apos; early growth.

ZHANG Zhuo-jun; WANG Yan-yan; YAO Wen; Ardythe Morrow; PENG Yong-mei

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Chinese Journal of Child Health Care ›› 2012, Vol. 20 ›› Issue (2) : 112-116.

Study on FUT2 gene polymorphism and the effect on breast-fed infants' early growth.

ZHANG Zhuo-jun¹,WANG Yan-yan¹,YAO Wen¹,Ardythe Morrow²,PENG Yong-mei¹

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Abstract

【Objective】 To examine the association between variation in mother's SNP genotype of FUT2 and infants' early growth and prevalence of common diseases. 【Methods】 110 breastfeeding mother-infant pairs were recruited in this study.Saliva samples were collected at 2 weeks postpartum.Infants' anthropometric indices like weight,height and head circumference were measured at the age of 4,13,26,52 w.The information of infants' sickness and diets were recorded by enquiring mothers by telephone. 【Results】 The incidence of common infectious diseases of this group of children was lower comparing with that published in the literature.Infants whose mothers' SNP genotype were AT grew faster than those whose mothers' SNP genotype were AA or TT.Their Z scores of weight at 13,26,52 w,height at 26,52 w and head circumference at 52 w were higher than those of other two groups (P<0.05),and their incidence of moderate to severe acute respiratory illness was lower (P<0.05);There were no significant differences of infants' incidence of eczema among different SNP genotype mothers' infants (P>0.05).However,the incidence of eczema of infants whose parents had atopic history was higher than whom they hadn't (P<0.05). 【Conclusions】 Breastfeeding could decrease the incidence of infants' common infectious diseases;AT maternal SNP (rs1047781) genotype of FUT2 profits infants more on early growth.Infants' incidence of eczema is associated with family history of hypersensitivity.

Key words

breast milk / neutral oligosaccharide / type α1,2 fucosyltransferase gene / genetic polymorphism / growth / incidence

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ZHANG Zhuo-jun,WANG Yan-yan,YAO Wen,Ardythe Morrow,PENG Yong-mei. Study on FUT2 gene polymorphism and the effect on breast-fed infants' early growth.[J]. Chinese Journal of Child Health Care. 2012, 20(2): 112-116

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