Abstract: 【Objective】 To analysis the outcome of IQ development in children with partial seizures,and research independent influential factors of the IQ development. 【Methods】 The IQ of 106 children with epilepsy who was diagnosed as partial seizures according to the results of symptoms,EEG and MRI were assessed.Children were categorized as normal IQ group (IQ≥80) and IQ dysfunction group (IQ<80) according to outcome of cognitive function. Univariate and multivariate Logistic regression analysis were used to determine influential factors of IQ development. 【Results】 Multivariate logistic regression analysis found age at oneset(P=0.000,OR=6.348,95%CI:2.290~17.599),seizure frequency (P=0.017,OR=3.479,95%CI:1.250~9.684),outcome of MRI(P=0.004,OR=4.849,95%CI:1.654~14.212),seizure type (P=0.011,OR=3.527,95%CI:1.330~9.349), numbers of anti-epileptic drugs(P=0.012,OR=3.862,95%CI:1.341~11.124) were the independent influential factors of IQ development.Epilepsy duration,age had no significant association with IQ development. 【Conclusions】 Early age at onset,high seizure frequency,MRI-positive,secondary generalized seizures and more numbers of anti-epileptic drugs indicate IQ development more easily impaired in children with partial seizures.

Key words: epilepsy, partial seizures, IQ development, influential factors, children

摘要： 【目的】 分析部分性发作癫痫患儿智力发育状况,研究影响部分性发作癫痫患儿智力发育的独立影响因素。 【方法】 对根据症候学、EEG及MRI检查等检查结果诊断为部分性发作的106例癫痫患儿进行智商测定,根据智商测定结果将患儿分为智力正常组(IQ≥80)和智力异常组(IQ<80)。经单因素和多因素 Logistic回归分析确定影响部分性发作癫痫患儿智力发育的因素。 【结果】 Logistic回归分析发现:首发年龄(P=0.000,OR=6.348,95%CI:2.290~17.599),发作频率(P=0.017,OR=3.479,95%CI:1.250~9.684),MRI检查结果(P=0.004,OR=4.849,95%CI:1.654~14.212),发作类型(P=0.011,OR=3.527,95%CI:1.330~9.349),服用抗癫痫药物量(P=0.012,OR=3.862,95%CI:1.341~11.124)为部分性发作癫痫患儿智力发育的独立影响因素。病程、年龄等因素与智力发育没有显著性关系。 【结论】 首发年龄小、发作频率高、MRI阳性、发作类型为继发全面性发作、服用抗癫痫药物量大的部分性发作癫痫患儿智力发育更容易受损。

关键词: 癫痫, 部分性发作, 智力发育, 影响因素, 儿童