Effects of prenatal blood lead exposure lower than 100 μg/L on infant&apos;s neurobehavioral development

WANG Bo; SHAO Di-chu; XIANG Zhang-hua; NI Wei-min; YANG Shui-lian; WU Cui-e; LI Ping-jian; FU Hua

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Chinese Journal of Child Health Care ›› 2011, Vol. 19 ›› Issue (6) : 505-508.

Effects of prenatal blood lead exposure lower than 100 μg/L on infant's neurobehavioral development

WANG Bo^1,2, SHAO Di-chu³, XIANG Zhang-hua³, NI Wei-min⁴, YANG Shui-lian⁴, WU Cui-e¹, LI Ping-jian¹, FU Hua¹

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Abstract

【Objective】 To determine the effects of prenatal lead exposure(lower than 100 μg/L) on six-month-old infant's growth and development. 【Methods】 The study subjects were 6-month-old infants whose mothers' blood lead were lower than 100 μg/L both during the 1^st and 3^rd trimester of gestation in a cohort study. Bayley infant development scale was used to evaluate the infants' development. The differences in mental development index(MDI) and psychomotor development index(PDI) of infant were compared across different prenatal blood exposure levels, using the P25, P50 and P75 of the blood lead during pregnancy as the dividing value of groups, respectively. 【Results】 The MDI and PDI of 6-month-old infants tended to decrease as the increase of prenatal blood lead exposure level. The PDI of 6-month-old infants in the relative high lead level group was lower than that in the relative low lead group as the dividing value of groups was P25 and P50 of blood lead, and the difference were statistically significant(P<0.05). There were no significant differences in the MDI of 6-month-old infants across groups. Besides, multivariate analysis indicated that the PDI of the infants whose prenatal lead concentration higher than P50 was 4.48 point lower than that of infants below P50. Similarly, the PDI of the infants whose prenatal lead concentration higher than P25 was 6.51 point lower than that of infants below P25. The differences were statistically significant. 【Conclusion】 Low level prenatal lead exposure may exert an influence on infants' behavior development and such effect might be more significant at the low level of lead exposure, which merits further research.

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blood lead / prenatal exposure / infant / development

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WANG Bo, SHAO Di-chu, XIANG Zhang-hua, NI Wei-min, YANG Shui-lian, WU Cui-e, LI Ping-jian, FU Hua. Effects of prenatal blood lead exposure lower than 100 μg/L on infant's neurobehavioral development[J]. Chinese Journal of Child Health Care. 2011, 19(6): 505-508

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