Reevaluate of vitamin D intoxication diagnosis of reported cases in recent years in China and the criteria diagnosis and treatment of vitamin D intoxication
- HU Yan-qi, SHENG Xiao-yang
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Abstract
【Objectives】 To reevaluate the diagnosis of vitamin D overdose and intoxication in reported cases in China, to improve the awareness of pediatricians on vitamin D overdose and intoxication, and to properly administrate vitamin D supplements. 【Methods】 All the cases of vitamin D overdose and intoxication reported from January 2004 till May 2010 in major domestic database had been searched by keywords "vitamin D", "overdose", "intoxication". The clinical manifestation, laboratory finding, treatment and prognosis of these cases had been reviewed. 【Results】 A total of 11 references had been searched. There were 475 cases of vitamin D overdose and intoxication had been reported in these references. Among them, 23 cases (4.8%) meet vitamin D intoxication diagnosis criteria; 17 cases (3.6%) were overdose of vitamin D; 234 cases (49.3%) could not be confirmed because incomplete information; 201 cases (42.3%) were misdiagnosis. 【Conclusions】 Almost half of cases are misdiagnosed vitamin D overdose and intoxication. Long-term prophylactic supplement vitamin D is very important to prevent and reduce vitamin D deficiency in children. However, precaution vitamin D abuse or misuse also should be emphasized.
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References
[1] 吴光驰,杨慕兰.我国儿童维生素D中毒与维生素D合理应用[J].中国儿童保健杂志,2004,12(6):512-513.
[2] 瞿平,刘友学,黎海芪.209例儿童维生素D过量分析[J].第三军医大学学报,2004,26(21):1985-1985.
[3] 钟小兰,亢安娜,余灵.婴幼儿维生素D中毒18例[J].人民军医,2004,47(5):285-286.
[4] 刘传玉.同胞双胎婴儿维生素D中毒报告[J].数理医药学杂志,2006,19(2):148-150.
[5] 王保华,戴晓慧.小儿维生素D中毒误诊1例[J].分析中国误诊学杂志,2007,7(6):1271-1271.
[6] 何少为.小儿维生素D中毒三例误诊分析[J].临床误诊误治,2006,19(3):87-88.
[7] 刘向东,刘静杰.小儿维生素D中毒30例临床观察[J].中华现代临床医学杂志,2005,3(23):2533-2536.
[8] 马树志,张贵成.婴幼儿VD3中毒临床分析[J].黑龙江医药,2007,20(2):177-180.
[9] 张立国,赵军波.小儿维生素D3中毒187例[J].中国煤炭工业医学杂志,2004,7(5):440-443.
[10] 姚永刚,周勇.口服维生素D3致中毒1例[J].医学理论与实践,2004,17(4):376-380.
[11] 李琨娥,李俐.维生素AD中毒3例误诊原因分析[J].西南军医,2004,6(6):27-28.
[12] 袁秀琴.维生素D中毒误诊为小儿厌食症5例报告[J].哈尔滨医药,2006,26(3):64-65.
[13] Cranney A, Weiler HA, O'Donnell S, et al. Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health[J].Am J Clin Nutr,2008,88(S): 513-519.
[14] Vieth R. Vitamin D toxicity, policy, and science[J]. J Bone Miner Res,2007,22(S2):64-68.
[15] Glenville J. Pharmacokinetics of vitamin D toxicity[J]. Am J Clin Nutr,2008,88(S): 582-586.
[16] Hathcock JN,Shao A,Vieth R,et al. Risk assessment for vitamin D[J]. Am J Clin Nutr, 2007,85:6-18.
[17] Misra M,Pacaud D,Petryk A,et al.Vitamin D deficiency in children and its management: review of current knowledge and recommendations[J]. Pediatrics,2008,122:398-417.
[18] Ezgu FS,Buyan N,Gunduz M,et al.Vitamin D intoxication and hypercalcaemia in an infant treated with pamidronate infusions[J].Eur J Pediatr,2004,163: 163-165.
[19] Bereket A,Erdogan T.Oral bisphosphonate therapy for vitamin D intoxication of the infant[J].Pediatrics,2003,111:899-901.
[20] Orbak Z,Doneray H,Keskin F,et al.Vitamin D intoxication and therapy with aldendr onate[J]. Eur J Pediatr,2006,165: 583-584.
[21] Wagner CL,Greer FR.Prevention of rickets and vitamin D deficiency in infants, children, and adolescents[J].Pediatrics,2008,122(5): 1142-1152.
[22] 《中华儿科杂志》编辑委员会,中华医学会儿科学分会儿童保健学组,全国佝偻病防治科研协作组.维生素D缺乏性佝偻病防治建议[J].中华儿科杂志,2008,46(3): 190-191.
[2] 瞿平,刘友学,黎海芪.209例儿童维生素D过量分析[J].第三军医大学学报,2004,26(21):1985-1985.
[3] 钟小兰,亢安娜,余灵.婴幼儿维生素D中毒18例[J].人民军医,2004,47(5):285-286.
[4] 刘传玉.同胞双胎婴儿维生素D中毒报告[J].数理医药学杂志,2006,19(2):148-150.
[5] 王保华,戴晓慧.小儿维生素D中毒误诊1例[J].分析中国误诊学杂志,2007,7(6):1271-1271.
[6] 何少为.小儿维生素D中毒三例误诊分析[J].临床误诊误治,2006,19(3):87-88.
[7] 刘向东,刘静杰.小儿维生素D中毒30例临床观察[J].中华现代临床医学杂志,2005,3(23):2533-2536.
[8] 马树志,张贵成.婴幼儿VD3中毒临床分析[J].黑龙江医药,2007,20(2):177-180.
[9] 张立国,赵军波.小儿维生素D3中毒187例[J].中国煤炭工业医学杂志,2004,7(5):440-443.
[10] 姚永刚,周勇.口服维生素D3致中毒1例[J].医学理论与实践,2004,17(4):376-380.
[11] 李琨娥,李俐.维生素AD中毒3例误诊原因分析[J].西南军医,2004,6(6):27-28.
[12] 袁秀琴.维生素D中毒误诊为小儿厌食症5例报告[J].哈尔滨医药,2006,26(3):64-65.
[13] Cranney A, Weiler HA, O'Donnell S, et al. Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health[J].Am J Clin Nutr,2008,88(S): 513-519.
[14] Vieth R. Vitamin D toxicity, policy, and science[J]. J Bone Miner Res,2007,22(S2):64-68.
[15] Glenville J. Pharmacokinetics of vitamin D toxicity[J]. Am J Clin Nutr,2008,88(S): 582-586.
[16] Hathcock JN,Shao A,Vieth R,et al. Risk assessment for vitamin D[J]. Am J Clin Nutr, 2007,85:6-18.
[17] Misra M,Pacaud D,Petryk A,et al.Vitamin D deficiency in children and its management: review of current knowledge and recommendations[J]. Pediatrics,2008,122:398-417.
[18] Ezgu FS,Buyan N,Gunduz M,et al.Vitamin D intoxication and hypercalcaemia in an infant treated with pamidronate infusions[J].Eur J Pediatr,2004,163: 163-165.
[19] Bereket A,Erdogan T.Oral bisphosphonate therapy for vitamin D intoxication of the infant[J].Pediatrics,2003,111:899-901.
[20] Orbak Z,Doneray H,Keskin F,et al.Vitamin D intoxication and therapy with aldendr onate[J]. Eur J Pediatr,2006,165: 583-584.
[21] Wagner CL,Greer FR.Prevention of rickets and vitamin D deficiency in infants, children, and adolescents[J].Pediatrics,2008,122(5): 1142-1152.
[22] 《中华儿科杂志》编辑委员会,中华医学会儿科学分会儿童保健学组,全国佝偻病防治科研协作组.维生素D缺乏性佝偻病防治建议[J].中华儿科杂志,2008,46(3): 190-191.
