Interaction of maternal pre-pregnancy body mass index and gestational weight gain on macrosomia

YU Chengdong; ZHANG Yaqin; WU Huahong; ZONG Xinnan; LI Hui

doi:10.11852/zgetbjzz2023-0110

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (11) : 1174-1179. DOI: 10.11852/zgetbjzz2023-0110

Original Articles

Interaction of maternal pre-pregnancy body mass index and gestational weight gain on macrosomia

YU Chengdong, ZHANG Yaqin, WU Huahong, ZONG Xinnan, LI Hui

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Abstract

Objective To explore the effects of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) during pregnancy and their additive interaction on macrosomia, and provide evidence for maternal weight management before and during pregnancy. Methods This study was based on the data of 12 040 pregnant women and full-term newborns surveyed in 13 cities of China from June 2015 to November 2018. According to China′s standards for overweight, obesity, and GWG, unconditional multivariate Logistic regression was performed to estimate the independent effect and additive interaction of pre-pregnancy BMI and GWG on macrosomia. Results With the increase of pre-pregnancy BMI category, the mean GWG decreased gradually (P_trend<0.001). After adjusting for other confounding factors, the results showed that pre-pregnancy overweight/obesity (OR=1.67, 95%CI: 1.35 - 2.05) and excessive GWG (OR=1.78, 95%CI: 1.48 - 2.16) increased the risk of macrosomia. The coexistence of pre-pregnancy overweight/obesity and excessive GWG further increased the risk of macrosomia, but the additive interaction between them was not found. Conclusions Pre-pregnancy overweight/obesity and excessive GWG are independent risk factors for macrosomia, but the interaction between them is not statistically significant. It is suggested that pregnant woman should keep normal weight before pregnancy and gain appropriate weight during pregnancy, especially those who are overweight/obese before pregnancy should keep lower GWG to reduce the risk of macrosomia in offspring.

Key words

body mass index / gestational weight gain / macrosomia / interaction

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YU Chengdong, ZHANG Yaqin, WU Huahong, ZONG Xinnan, LI Hui. Interaction of maternal pre-pregnancy body mass index and gestational weight gain on macrosomia[J]. Chinese Journal of Child Health Care. 2023, 31(11): 1174-1179 https://doi.org/10.11852/zgetbjzz2023-0110

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