Abstract
Objective To analyze the effect of methylphenidate hydrochloride prolonged-release tablets on the growth and nutritionl intake of children with attention deficit hyperactivity disorder (ADHD), in order to provide scientific reference for drug therapy of ADHD. Methods ADHD children in Children′s Hospital of Nanjing Medical University were selected as study subjects, and were divided into treatment group and control group. The treatment group was given methylphenidate hydrochloride sustained release tablets, while the control group received behavior management. Height, weight, body composition measurement and 24 hour dietary survey analysis were monitored regularly. Results The Z scores of weigh-for-age(W/A-Z) (t= 5.815, 6.708, 5.003, 2.234, P<0.001) andthe Z scores of body mass index-for-age(BMI/A-Z) (t=3.776, 4.666, 6.431, 7.467, P<0.001), body composition measurement of protein content (t=3.789, 4.087, 3.098, 2.889, P=0.001), skeletal musclecontent (t=3.112, 2.890, 4.765, 5.221, P<0.001),fat content (t=4.329, 3.879, 2.998, 2.567, P<0.001); 24-hour dietary assessment of energy (t=11.657, 12.887, 5.091, 3.765, P<0.001), protein (t=12.987, 14.098, 13.777, 12.987, P<0.001), fat (t= 12.889, 12.012, 14.887, 13.987, P<0.001) and carbohydrate intake (t= 13.889, 14.889, 15.098, 14.889, P<0.001)after 3-month,6-month,9-month,and 12-month treatmentwere lower than those in control group. The Z scrores of height-for-age (H/A-Z) of children in the treatment groupafter 6-month, 9-month and 12-month treatment were lower than those in control group(t=1.752, 2.625,5.961,P＜0.001). Repeated measurement anova analysis showed that the time effect, intragroup effect and interaction effect of physical assessment, body composition (except for inorganic salts) and 24-hour dietary assessment between the treatment group and control group were statistically significant (P<0.05). Conclusion The medication of methylphenidate hydrochloride prolonged-release tablets on ADHD children, with the treatment duration increasing, will have an impact on the height, weight, BMI and nutritionl intake of children.
Key words
attention-deficit hyperactivity disorder /
medication /
growth /
children
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LI Rong, LI Nian, WU Dandan, HUANG Rong, CHEN Yinhua.
Effect of methylphenidate hydrochloride prolonged-release tablets on the growth of children with attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2023, 31(7): 731-735 https://doi.org/10.11852/zgetbjzz2022-1339
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