Research progress of neural network basis on social brain in autism spectrum disorder

YU Han; QU Hang; ZHAO Yi; PAN Yu; WANG Wei

doi:10.11852/zgetbjzz2021-1270

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (12) : 1350-1353. DOI: 10.11852/zgetbjzz2021-1270

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Research progress of neural network basis on social brain in autism spectrum disorder

YU Han, QU Hang, ZHAO Yi, PAN Yu, WANG Wei

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Abstract

Autism spectrum disorder(ASD) is a heterogeneous neurodevelopmental disorder characterized by impairments in social communication and restricted and repetitive behaviors and interests,with symptom onset during the first few years of life. Over the past two decades,neuroimaging has revealed numerous findings of atypical activity and abnormal connectivity of "social brain" networks,including analysis of faces and gaze by the fusiform face area(FFA),emotional processing in the amygdala,mentalizing in the default mode network(DMN) and imitation and understanding of others′ actions by the regions associated with the mirror neuron system(MNS),yet no consensus view on crucial developmental causes of social communications deficits has emerged. Aside from methodological challenges and studies on the connectivity of individual brain networks,the deeper problem concerns the strong heterogeneity of ASD. This inconsistent finding may be due to changes in diagnostic criteria and the atypical neurodevelopment trajectories of autism at preschool period. Therefore,cohort studies on subtypes of autism and of longitudinal cohort with a large sample are warranted.

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autism spectrum disorder / social communication / social network / social brain

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YU Han, QU Hang, ZHAO Yi, PAN Yu, WANG Wei. Research progress of neural network basis on social brain in autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2022, 30(12): 1350-1353 https://doi.org/10.11852/zgetbjzz2021-1270

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