Objective To understand and explore the depression status and its influencing factors among children and adolescent students during the prevalence of the coronavirus disease 2019 (COVID-19),in order to provide reference for the psychological intervention for students in this area. Methods A self-designed general data questionnaire,Depression Self-rating Scale for Children (DSRS)and the Screen for Child Anxiety Related Emotional Disorders (SCARED) were typed in www.wjx.cn.And the questionnaire was sent out to children and adolescent aged 8 to 18 years by Wechat APP from February 6th to 8th,2020.Univariate and multivariate analysis were used to analyze the influencing factors associated with NCP by SPSS 22.0 software. Results Totally 396 valid questionnaire were returned.The average score of DSRS score was 7.35±5.10.Using 15 as the cut point of having depression symptoms,it was found that 41 students (10.4%) had depression symptoms obviously.Multivariate analysis showed that anxiety score,dwelling area,fear of the COVID-19 prevalence and age were influencing factors of DSRS score (P＜0.05).Logistic analysis indicated that anxiety (OR=4.284,95%CI:2.163~8.486,P＜0.001),dwelling in suburban and rural areas (OR=2.382,95%CI:1.120~5.069,P=0.024),and fear of COVID-19 related events (OR=3.312,95%CI:1.210~9.064,P=0.020) were risk factors for depression of children and adolescent with home quarantine. Conclusions Psychological intervention should be strengthen in children and adolescents by family,school and the society,so as to reduce the panic and anxiety in children.Moreover,it is suggested to give more concern to older children in high grade as well as child and adolescent dwelling in suburban and rural areas,thereby reducing the depression of them during the COVID-19 prevalence.