Objective To evaluate the mental health status of students aged 8 to 18 during the period of home isolation in the prevalence of coronavirusdisease 2019(COVID-19), so as to provide a basis for psychological counseling for students in special periods. Methods A total of 396 students aged from 8 to 18 were assessed for anxiety/depression by Questionnaire Star survey on February 6th to 8th, 2020.All subjects filled out general information and the Screen for Child Anxiety Related Emotional Disorders(SCARED) were analyzed for the impact of COVID-19 on children′ and adolescents′ mood and anxiety during home isolation. Results 1) The total score of SCARED in 396 students was 16.44±12.30, 87 (22.0%) with scores≥25 and 309 (78.0%) with scores＜25.The mean scores of 5 factors(somatization/panic, generalized anxiety, dissociative anxiety, social phobia and school phobia) and the total scores were compared between the two groups, and the differences were statistically significant (t=13.156, 19.524, 10.381, 13.964, 7.325, 23.371, P＜0.001).2) Binary Logistic regression analysis showed that female students (OR=2.258, 95%CI:1.370—3.721, P＜0.001) and considering themselves in danger (OR=1.978, 95%CI :1.185—3.301, P=0.009) were risk factors for anxiety among students isolated at home during the epidemic. Conclusionss The prevalence of COVID-19 has some influence on students′ mood, especially for girls.Parents, schools and society should take timely measures to guide students to avoid anxiety in special times.