Amplitude of low frequency fluctuation study on brain in children with attention deficit hyperactivity disorder-based on near infrared imaging technology

LIAO Wen-jing; ZHU Zhao-jun; NIU Hai-jing; QIAN Qiu-jin; WANG Yu-feng

doi:10.11852/zgetbjzz2019-0958

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (1) : 19-22. DOI: 10.11852/zgetbjzz2019-0958

Amplitude of low frequency fluctuation study on brain in children with attention deficit hyperactivity disorder-based on near infrared imaging technology

LIAO Wen-jing¹, ZHU Zhao-jun², NIU Hai-jing², QIAN Qiu-jin³, WANG Yu-feng³

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Abstract

Objective Using near infrared spectroscopy (NIRS)to investigate spontaneous activity′s characteristics of the brain area in the resting-state and the correlation with clinical symptomsin in children with attention deficit hyperactivity disorder(ADHD), and then explore the pathological mechanism of ADHD. Methods A total of 20 ADHD children and 20 normal controls matched by sex and age were collected from March to June 2017.The Chinese Wechsler Intelligence Scale for Children, ADHD symptom rating questionnaire were used to access intelligence quotient and clinical symptoms.NIRS was used to collect brain images.The amplitude of low-frequency fluctuation (ALFF) and Pearson partial correlation analysis were used to explore the differences of brain function and the correlation with clinical symptoms of ADHD. Results 1)Children with ADHD had higher ALFF in right dorsolateral prefrontal cortex, right pre-motor and supplementary motor cortex, left dorsolateral prefrontal cortex and frontopolar area, left superior/ middle temporal gyrus and primary auditory association cortex, left inferior prefrontal gyrus, left orbitofrontal area than control subjects(t=-2.48,-2.41,-2.66,-2.12,-2.51,-0.039,P<0.05).2)In the ADHD group, the associations between the scores of hyperactivity and impulsivity with left inferior prefrontal gyrus, orbitofrontal area, frontopolar area(r=0.562,P=0.036)and left superior/middle temporal gyrus, primary auditory association cortex(r=0.541, P=0.046) were positive(P<0.05). Conclusions Brain functional abnormalities contributed to the emergence of ADHD.Children with ADHD probably have higher spontaneous activity of the brain area in the resting state.The brain functional connectivity was associated with the severity of hyperactivity impulsive symptoms in ADHD.

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attention deficit hyperactivity disorder / near infrared imaging / resting state / amplitude of low frequency fluctuation

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LIAO Wen-jing, ZHU Zhao-jun, NIU Hai-jing, QIAN Qiu-jin, WANG Yu-feng. Amplitude of low frequency fluctuation study on brain in children with attention deficit hyperactivity disorder-based on near infrared imaging technology[J]. Chinese Journal of Child Health Care. 2020, 28(1): 19-22 https://doi.org/10.11852/zgetbjzz2019-0958

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