Objective To analyze the functional connectivity characteristics between primary auditory brain regions and whole brain in resting state in children with autism spectrum disorder (ASD),and to explore the correlation with sensory behaviors. Methods The fMRI data of 34 ASD boys and 29 healthy boys were collected.And BA41/42,which was related to primary auditory,was used as the seed region to generate intrinsic functional connectivity maps based on resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to identify brain regions with altered connectivity.Short Sensory Profile (SSP) was used to assess the sensory behaviors of ASD children.Correlation between the altered functional connectivity and sensory behaviors in ASD children was examined by Pearson analysis. Results ASD group had decreased functional connectivity between BA41/42 and left posterior cingulate gyri,and it was negatively correlated with tactile sensitivity,taste/olfactory sensitivity and total scale scores in the SSP scale (r=-0.496,-0.420,-0.415,P<0.05).ASD group had increased functional connectivity between BA41/42 and left median cingulate and paracingulate gyri,and there was a negative correlation with tactile sensitivity,low response/seeking stimulus,auditory filtering,and total score of the SSP scale(r=-0.650,-0.499,-0.447,-0.541,P＜0.05),and a positive correlation with SSP level,including tactile sensitivity,taste/olfactory sensitivity,motor sensitivity,low response/seeking stimulation,low strength/weakness,and total scale score (r=0.423,0.527,0.467,0.471,0.470,0.642,P＜0.05).And ASD group had increased functional connectivity between BA41/42 and left supplementary motor area. Conclusion ASD children have abnormal functional connectivity characteristics between primary auditory brain regions and whole brain in resting state,providing an objective evidence of brain functional connectivity for abnormal sensory behaviors.
Key words
autism spectrum disorder /
primary auditory brain regions /
resting-state functional connectivity magnetic resonance imaging /
brain connectivity /
sensory behavior
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] American Psychiatric Association.Diagnostic andstatistical manual of mental disorders,fifth edition[M].Washington DC:American Psychiatric Association,2013:50-51.
[2] Baio J,Wiggins L,Christensen DL,et al.Prevalence of autism spectrum disorder among children aged 8 years- autism and developmental disabilities monitoring network,11 Sites,United States,2014[J].MMWR Surveill Summ,2018,67(6):1-23.
[3] McIntosh DN,Miller LJ,Shyu V,et al.Sensory modulation disruption,electrodermal responses,and functional behaviors[J].Dev Med Child Neurol,1999,41(9):608-615.
[4] 王元青.孤独症患儿听觉异常行为的研究[J].中国妇幼保健杂志,2013,28 (22):3599-3601.
[5] 杨剑,陈书燊,皇甫浩然,等.静息态脑电信号动态功能连接分析[J].物理学报,2015,64(5):382-391.
[6] Oblak AL,Rosene DL,Kemper TL,et al.Altered posterior cingulate cortical cyctoarchitecture,but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism[J].Autism Res,2011,4(3):200-211.
[7] Padmanabhan A,Lynch CJ,Schaer M,et al.The default mode network in autism[J].Biol Psychiatry Cogn Neurosci Neuroimaging,2017,2(6):476-486.
[8] Washington SD,Gordon EM,Brar J,et al.Dysmaturation of the default mode network in autism[J].Hum Brain Mapp,2014,35(4):1284-1296.
[9] Jann K,Hernandez LM,Beck-Pancer D,et al.Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder[J].Brain Behav,2015,5(9):e00358.
[10] Abbott AE,Nair A,Keown CL,et al.Patterns of atypical functional connectivity and behavioral links in autism differ between default,salience,and executive networks[J].Cereb Cortex,2016,26(10):4034-4045.
[11] Bi XA,Liu YC,Qin J,et al.The diagnosis of autism s pectrum disorder based on the random neural network cluster[J].Front Hum Neuro Sci,2018,12:257.
[12] Wang W,Liu J,Shi S,et al.Altered resting-state functional activity in patients with autism spectrum disorder:A quantitative Meta-analysis[J].Front Neurol,2018,9:556.
[13] 王薇薇,吴逊.扣带回的解剖、生理及扣带回癫[J].中国现代神经疾病杂志,2018,18(5):315-323.
[14] Nair A,Carper RA,Abbott AE,et al.Regional specificity of aberrant thalamocortical connectivity in autism[J].Hum Brain Mapp,2015,36(11):4497-4511.
[15] Mosconi MW,Sweeney JA.Sensorimotor dysfunctions as pr imary features of autism spectrum disorders[J].Sci China Life Sci,2015,58(10):1016-1023.
[16] Caroline W,Cathy C.Sensory-motor problems in autism[J].Front Integr Neuro Sci,2013,7:51.
[17] 李世俊.学龄前孤独症儿童脑部多模态磁共振成像的研究[D].北京:中国人民解放军医学院,2015.
[18] Baum SH,Stevenson RA,Wallace MT.Behavioral,perceptual,and neural alterations in sensory and multisensory function in autism spectrum disorder[J].Prog Neurobiol,2015,134:140-160.
PDF(785 KB)
