Objective To study the correlation between inflammatory cytokines and autism spectrum disorder (ASD),and to identify serum markers for diagnosis and treatment of ASD. Methods A total of 70 ASD patients and 70 normal control children in Zhuhai Municipal Maternal and Child Health Care Hospital were enrolled in this study from June 2015 to May 2017.And 11 kinds of inflammatory cytokines such as GM-CSF,IL-5,IL-13,MIG,MIP-1α,MIP-1β,PDGF- BB,RANTES,TIMP-1,TIMP-2 and TNF RⅡ in serum samples from were tested by protein chip technology were tested. Results There were significant differences on the levels of GM-CSF,IL-5,IL-13,MIG and MIP-1α between the case group and control group (t=4.857,2.364,4.024,2.209,-5.054,all P<0.05).The levels of GM-CSF,IL-5,IL-13 and MIG in the case group were higher than those in the control group,while the level of MIP-1α was lower in the case group.Also,the level of MIP-1α was associated with mental retardation in ASD children. Conclusions Increased levels of serum GM-CSF,IL-5,IL-13,MIG and decreased MIP-1α are associated with the pathogenesis of ASD.And low level of MIP-1α is closely linked with mental retardation in children with ASD.This conclusion provides the scientific basis for early intervention in ASD children from neuro-immunology point of view.
Key words
autism spectrum disorder /
inflammation /
cytokines /
mental retardation
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References
[1] American Psychiatric Association.Diagnostic and statistical manual of mental disorders, fifth edition(DSM-5TM)[M].Washington DC:American Psychiatric Publishing,2013:50-59.
[2] 李洪华,杜琳,单玲,等.孤独症谱系障碍流行病学研究现状[J].中华临床医师杂志:电子版,2014,8(24):4471-4474.
[3] 朱静.孤独症谱系障碍的神经免疫学研究进展[J].中国儿童保健杂志,2015,23(9):956-958.
[4] 尹苹,孙若鹏.生命早期炎症对惊厥易感性及相关脑损伤的影响[D].济南:山东大学,2014:95-118.
[5] Filiano AJ,Gadani SP,Kipnis J.Interactions of innate and adaptive immunity in brain development and function[J].Brain Res,2015,18(1617):18-27.
[6] Jiang HY,Xu LL,Shao L,et al.Maternal infection during pregnancy and risk of autism spectrum disorders: a systematic review and meta-analysis[J].Brain Behav Immun,2016,58:165-172.
[7] Ross HE,Guo Y,Coleman K,et al.Association of IL-12p70 and IL-6:IL-10 ratio with autism-related behaviors in 22q11.2 deletion syndrome: a preliminary report[J].Brain Behav Immun,2013,31:76-81.
[8] Xie J,Huang L,Li X,et al.Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children[J].Oncotarget,2017,8(47):82390-82398.
[9] 肖鸽飞,周翔,周玉球,等.血清炎性细胞因子与孤独症谱系障碍相关性的探讨[J].国际检验医学杂志,2016,37(15):2131-2133.
[10] Shen Y,Ou J,Liu M,et al.Altered plasma levels of chemokines in autism and their association with social behaviors[J].Psychiatry Res,2016,244:300-305.
[11] Zerbo O,Yoshida C,Grether JK,et al.Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study:a case-control study[J].J Neuroinflammation,2014,11:113.
[12] Sieber MW,Claus RA,Witte OW,et al.Attenuated inflammatory response in aged mice brains following stroke[J].PLoS One,2011,6(10):e26288.
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