Objective To analyze the related factors of multiple drug resistant bacteria infection in children with severe bacterial pneumonia. Methods A retrospective analysis was conducted from January 2011 to November 2015 to collect clinical data of 457 cases of children with bacterial severe pneumonia including 96 cases of multi drug resistant bacteria infection patients and 361 cases of non multi drug resistant bacteria infection of difference.Related factors analyzed by multivariate Logistic regression analysis. Results A total of 96 patients were with multi drug resistant strains of bacteria,including 68 males,28 females,aged 0~14 years old,and the average age was(6.09±4.51) years old.And 361 patients were without multi-drug resistant strains of bacteria,including 228 males,133 females,the average age was (5.34±4.63) years old.Multifactors analysis showed that the previous use of antimicrobial agents[OR=1.093,95%CI(1.014~1.179)],in PICU days [OR=3.613,95%CI(1.874~6.969)],and traumatic treatment after infection [OR=2.296,95%CI(1.141~4.619)],combined application of antibiotics [OR=6.861,95%CI(3.510~13.409)],antibiotic use days after infection [OR=1.295,95%CI(1.125~1.409)] were the main factors of multi drug resistant bacteria infection in children with severe bacterial pneumonia (P<0.05). Conclusion Effective measures should be taken to prevent and reduce the multiple drug resistant bacteria infection in children with bacterial pneumonia.
Key words
bacteria /
severe pneumonia /
multi-drug resistant bacteria /
risk factors /
children
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] O'Brien M.The reciprocal relationship between inflammation and coagulation[J].Top Companion Anim Med,2012,27(2):46-52.
[2] Levi M,van der Poll T,Schultz M.Systemic versus localized coagulation activation contributing to organ failure in critically ill patients[J].Semin Immunopathol,2012,34(1):167-179.
[3] 刘慧,肖新才,陆剑云,等.2009-2012年广州市社区获得性肺炎流行特征和病原学研究[J].中华预防医学杂志,2013,47(12):1089-1094.
[4] 刘霞,马静,张忠晓,等.儿童重症肺炎2044例肺泡灌洗液细菌病原学分析[J].中国实用儿科杂志,2014,29(6):438-441.
[5] 周剑昕,赵凯,赵若愚,等.儿童细菌性肺炎血清降钙素原、白细胞介素、肿瘤坏死因子及全血超敏C-反应蛋白的检测意义[J].儿科药学杂志,2014,20(11):1-4.
[6] Magiorakos AP,Srinivasan A,Carey RB,et al.Multidrugresistant,extensively drug-resistant and pandrug-resistant bacteria:an international expert proposal for interim standard definitions for acquired resistance[J].Clin Microbiol Infect,2012,18(3):268-281.
[7] 陈新,周林,钟威达.儿童细菌性肺炎的病原菌及其耐药状况分析[J].中华妇幼临床医学杂志:电子版,2012,8(2):199-201.
[8] 邹享珍,于梅芳,吕娟,等.东莞樟木头355例儿童细菌性肺炎细菌分布情况及药敏分析[J].中国实验诊断学,2015,19(4):590-592.
[9] 温壮飞,孙虹,卓珠琳,等.儿童社区获得性肺炎革兰氏阴性多重耐药菌的分布与耐药率分析[J].海南医学,2016,27(10):1625-1628.
[10] Fernández Jonusas S,Brener Dik P,Mariani G,et al.Nosocomial infections in a neonatal unit:surveillance program[J].Arch Argent Pediatr,2011,109(5):398-405.
[11] Yapicioglu H,Ozcan K,Sertdemir Y,et al.Healthcare-associated infections in a neonatal intensive care unit in Turkey in 2008:incidence and risk factors,a prospective study[J].Journal of Tropical Pediatrics,2011,57(3):157-164.
[12] 方根,国钰梅.ICU患者下呼吸道感染铜绿假单胞菌耐药分析及临床对策[J].中国社区医师:医学专业,2013,15( 6):26-27.
[13] Wu D,Cai J,Liu J.Risk factors for the acquisition of nosocomial infection with carbapenem-resistant Klebsiella pneumoniae[J].South Med J,2011,104(2):106-110.
PDF(562 KB)
