Objective To examine the predictors of rapid gain of body mass index (BMI) in infants from birth to 1 year old,and to povide the reference basis about whether there was an interaction between gestational age and birth weight percentile on rapid gain of BMI in infants. Methods A retrospective cohort study was conducted using the electronic medical record system of Maternal and Child Health Care in Zhongshan,Guangdong,China.A total of 786 infants born form January 2011 to May 2013 were errolled in this study,and completed their one-year regular child visit within 3 months before or after 12 months of age.Univariate and multivariable Logistic regression analysis were used to identify significant predictors. Results Multivariable Logistic regression analysis indicated that gestational age,birth weight percentile and maternal education were significant predictors of rapid gain of BMI in infants from birth to 1 year old.Compared with full-term infants,preterm infants were more likely (OR=19.88,95%CI:10.24~38.59) to have rapid gain of BMI in infants.Compared with appropriate for gestational age (AGA) infants,small for gestational age (SGA) infants were more likely (OR=4.59,95%CI:2.56~8.23) to have rapid gain of BMI,while large for gestational age (LGA) infants were less likely (OR=0.29,95%CI:0.12~0.69) to have rapid gain of BMI.Children whose mothers were with college degree or higher education level were less likely (OR=0.38,95%CI:0.18~0.78) to have rapid BMI gain than children whose mothers were with middle school or lower education level.There was no significant interaction between gestational age and birth weight percentile on rapid gain of BMI in infants (P>0.05). Conclusions Preterm and SGA are independent risk factors (without interaction) for rapid gain of BMI in infants from birth to 1 year of age,while high maternal education may protect against rapid BMI gain.
Key words
accelerated growth /
preterm /
small for gestational age /
appropriate for gestational age /
large for gestational age
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