Objective To understand the prevalence of bronchopulmonary dysplasia(BPD) in premature infants,and to analyze the relevant factors for BPD,in order to provide evidence for clinical prevention and treatment. Methods A total of 1 426 premature infants born in Xinjiang Uygur Autonomous Region People′s Hospital were enrolled in the study from January 2015 to June 2018,and were divide into BPD group and control group.The clinical data of puerperae and neonates were compared between the two groups.And univariate analysis and multivariate Logistic regression analysis were used to find out the risk factors of BPD. Results Among 1 426 premature infants,88(6.17%) cases suffered from BPD,including 23(26.14%) mild cases,49(55.68%) moderate cases and 16(18.18%) severe cases.Univariate analysis showed that maternal age,gestational hypertension,long-term smoking or second-hand smoking,overwork,intrauterine infection,amnionitis,and neonatal gestational age,birth body weiyht,1 min Apgar score,neonatal acute respiratory distress syndrome(NRDS),pneumorrhagia,intracranial hemorrhage,retinopathy,anemia,mechanical ventilation,pulmonary surfactant(PS) use,oxygen use time and maximum oxygen concentration>40% were associated with the BPD in premature infants(P<0.05).Multivariate Logistic regression analysis showed that intrauterine infection of puerperae(OR=3.300,95%CI:1.367-7.967),and gestational age ≤28 weeks(OR=4.162,95%CI:2.379-7.281),birth body weight<1 500 g(OR=4.591,95%CI: 2.926-7.202),pneumorrhagia(OR=2.654,95%CI: 1.329-5.300),anemia(OR=5.836,95%CI: 2.129-15.993),and mechanical ventilation(OR=4.033,95%CI: 1.953-8.175) were risk factors for BPD in premature infants(P<0.05). Conclusions BPD in premature infants is related to intrauterine infection,preterm gestational age,birth body weight,presence or absence of pneumorrhagia,anemia and mechanical ventilation.Clinical prevention and treatment measures are supposed to be made according to maternal and neonatal conditions so as to reduce the incidence of BPD and to improve the survival rate and quality of life of premature infants.
Key words
premature infants /
bronchopulmonary dysplasia /
risk factors
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