Non-randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of children with Rett syndrome

doi:10.11852/zgetbjzz2018-1810

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (7) : 771-774. DOI: 10.11852/zgetbjzz2018-1810

Non-randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of children with Rett syndrome

WANG Chao^1,2, LI Hui-ping¹, ZHOU Bing-rui¹, LI Chun-yang¹, ZHANG Ying¹, DONG Ping¹

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Abstract

Objectives To investigate the efficacy of repetitive transcranial magnetic stimulation(rTMS) in the treatment of Rett syndrome(RTT),so as to provide reference for clinical treatment. Methods Totally 17 children with Rett syndrome who met the criterion were enrolled in this study from January 2015 to April 2018,and were non-randomly divided into the TMS group(n=7) and control group(n=10). The TMS group was given rTMS for 6 months,while the control group received routine follow-up. All children were tested for MECP2 gene and were assessed by Griffiths Mental Development Scale-Chinese Version(GDS-C),Peabody Development Motor Scales(PDMS),Children′s Sleep Habits Questionnaire(CSHQ),flash visual evoked potential(FVEP) and brainstem auditory evoked potential(BAEP) at admission and 6 months respectively. Results 1) The overall development and motor ability of the children in TMS group and control group showed obviously degenerative changes,but the differences between the two groups were not significant(P＞0.05). 2) The sleep duration of children in TMS group and control group was shorter. After 6 months of rTMS intervention in TMS group,the average sleep duration of children in TMS group was longer than that of control group,but there was no significant difference between the two groups[ΔTMS group:(0.83±0.97) h vs. Δ control group:(-0.40±1.20) h,P＞0.05]. 3) There were no significant changes on the results of FVEP and BAEP before and after treatment,so was the difference between the two groups(P＞0.05). 4) rTMS was safe during treatment and no adverse events were reported. Conclusions Repeated transcranial magnetic stimulation may prolong the sleep duration and improve the quality of sleep in RTT children. Moreover,rTMS treatment has no significant effect on the progression of mental and motor developmental levels in RTT children,as well as the parameters of FVEP and BAEP. Meanwhile,there are no serious adverse reactions during the use of rTMS

Key words

repetitive transcranial magnetic stimulation / Rett syndrome / sleep duration / psychomotor development / visual evoked potential / auditory evoked potential

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WANG Chao, LI Hui-ping, ZHOU Bing-rui, LI Chun-yang, ZHANG Ying, DONG Ping. Non-randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of children with Rett syndrome[J]. Chinese Journal of Child Health Care. 2019, 27(7): 771-774 https://doi.org/10.11852/zgetbjzz2018-1810

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