Clinical study on vitamin K1 and protein induced by vitamin K absence or antagonist-Ⅱ in  neonatal umbilical cord blood

FAN Xiao-gang; XI Sha; WANG Ya-qin; XIAO Mi; CHEN Ru-juan; WANG Fang-hui; LIN Xiao-jie; LIU Li

doi:10.11852/zgetbjzz2018-1256

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (6) : 659-663. DOI: 10.11852/zgetbjzz2018-1256

Clinical study on vitamin K₁ and protein induced by vitamin K absence or antagonist-Ⅱ in neonatal umbilical cord blood

FAN Xiao-gang¹, XI Sha¹, WANG Ya-qin², XIAO Mi¹, CHEN Ru-juan¹, WANG Fang-hui¹, LIN Xiao-jie¹, LIU Li¹

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Abstract

Objectives To investigate the level of vitamin K₁ (VK₁)and protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ) in neonatal umbilical cord blood of different gestational age,and to discuss the influencing factors,so as to provide the basis for prevention and treatment of vitamin K deficiency hemorrhage and the application of vitamin K in clinical practice. Methods Neonates who did not have prophylactic use of vitamin K₁ born in the First Affiliated Hospital of Xi′an Jiaotong University and Shaanxi People′s Hospital from December 2016 to March 2017 were enrolled in this study,and the umbilical cord blood of 100 neonates were collected by random number method.The level of VK₁ was tested by high performance liquid chromatography-mass spectrometry,and the level of PIVKA-Ⅱ was tested by ELISA.Maternal history and related abnormal factors were investigated and recorded. Results The levels of VK₁and PIVKA-Ⅱin 100 neonates were (0.293±0.135) ng/ml and (22.479 ± 13.151) AU/ml.The level of VK₁ was negatively related to that of PIVKA-Ⅱ(r=-0.362,P<0.001).The levels of VK₁ and PIVKA-Ⅱin neonatal umbilical cord blood were significantly different on the maternal education level,residence place and the intake of green vegetables during pregnancy (P＜0.05).Moreover,the amount of green vegetables intake was independently influencing factors for the levels of VK₁ and PIVKA-Ⅱ (P<0.05). Conclusions Neonates have high level of VK₁ and low level of PIVKA-Ⅱ in umbilical cord blood.The rate of subclinical and clinical vitamin K deficiency is higher,so it is crucial to monitor the levels of PIVKA-Ⅱand vitamin K for pregnant women and newborn infants.Increasing green vegetable intake during pregnancy and timely monitoring the levels of PIVKA-Ⅱand vitamin K for pregnant women and newborn infants,will help to prevent and find the subclinical and clinical vitamin K deficiency early.

Key words

vitamin K₁ / PIVKA-Ⅱ / vitamin K deficiency bleeding / influencing factors

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FAN Xiao-gang, XI Sha, WANG Ya-qin, XIAO Mi, CHEN Ru-juan, WANG Fang-hui, LIN Xiao-jie, LIU Li. Clinical study on vitamin K₁ and protein induced by vitamin K absence or antagonist-Ⅱ in neonatal umbilical cord blood[J]. Chinese Journal of Child Health Care. 2019, 27(6): 659-663 https://doi.org/10.11852/zgetbjzz2018-1256

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