Objective To analyse the efficacy of different age to begin comprehensive intervention and duration of comprehensive intervention of children with autism spectrum disorders (ASD),and to provide a reference for improving the quality of life of children with ASD. Methods A total of 221 children were diagnosed as ASD according to American Psychiatric Diagnostic Statistical Manual 4^th edition criteria (DSM-Ⅳ) and conducted the self controlled study of comprehensive intervention treatment.Autism Behavior Checklist (ABC) was used to analyse the efficacy. Results There were significant differences in scores of feeling,sports,language,and social/self-control factors of ABC between before and after therapy,between different age to start comprehensive intervention and comprehensive intervention duration(P<0.000 1).Started earlier and the longer duration of comprehensive intervention,the differences of the each factor and total scores of ABC rating scale were statistically significant. Conclusions Comprehensive intervention can improve the ASD abilities of feeling,sports,language,and social/self-control.At the same time,the more effective is by younger to start comprehensive intervention and longer duration of comprehensive intervention.