Objective To study body growth rate in hospitalization and its correlative influencing factors of very low birth weight infants(VLBWI),and provide help for the treatment of VLBWI in the future clinical work. Methods A total of 105 VLBWI in NICU were selected.Their weight,length and head circumference were measured regularly for growth curve chat.The growth rate of weight,length and head circumference and its correlative influencing factors were analyzed. Results The weight of intrauterine growth retardation (IUGR) 17 cases (16.19%),and extrauterine growth retardation (EUGR) 41 cases (39.05%),the length of IUGR 22 cases (20.95%),EUGR 35 cases (33.33%),the head circumference of IUGR 9 cases (8.57%),and EUGR 15 cases (15.24%).The weight of EUGR group and non EUGR group:rates of maternal premature rupture of membranes,intrauterine infection in EUGR group were significantly higher than those in non EUGR group,there were significant differences between two groups (P<0.05);The incidence rates of chronic lung disease,sepsis,patent ductus arteriosus (PDA) in EUGR group during hospitalization were significantly higher than those in non EUGR group,there were significant differences between the two groups (P<0.05);CPAP ventilation time rate and time of tracheal intubation and assisted ventilation in EUGR group were significantly higher than those in non EUGR group,there were significant differences between the two groups (P<0.05). Conclusions The VLBWI management need to pay attention to depict the growth curve,which shows the downward trend of children and find out the reasons in time for timely intervention.The monitoring and prevention of premature rupture of membranes,intrauterine infection,and active treatment chronic lung disease,sepsis,PDA and other complications during hospitalization,is the key to prevent the very low birth weight infants' EUGR.