Objective To explore the relationship between marginal vitamin A deficiency and respiratory tract infections in children and its risk factors. Methods One hundred and sixty children between April 2015 and October 2015 were enrolled in the study,including 42 cases of RRI in acute infection (A group),24 cases of repeated respiratory infection (RRI) in non-acute infection (B group),18 cases of acute respiratory tract infection (C group) and 76 health children (D group).The serum vitamin A level was measured by high performance liquid chromatography (HPLC).Serum VA level ranged from 0.20 to 0.30 mg/L was considered as marginal vitamin A deficiency (MVAD). Results 1)The serum VA levels of A group[(0.27±0.07) mg/L],B group[(0.28±0.04) mg/L] and C group[(0.28±0.09) mg/L] were lower than those of D group[(0.33±0.08) mg/L] (P<0.05).2)The incidence of MVAD in RRI children was significantly higher than that in non-RRI children (P<0.05).3)Logistic regression analysis showed that living in rural area,poor appetite and having acute respiratory infection all were risk factors for MVAD. Conclusions Vitamin A deficiency may be one of the important reasons of RRI in children,and acute infection can aggravate the lack of VA in vivo.Children who were living in rural area,with poor appetite or having acute respiratory infection,were more susceptible for MVAD.
Key words
marginal vitamin A deficiency /
repeated respiratory infection /
acute infection /
child
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Wong AY,Chan EW,Chui CS,et al.The phenomenon of micronutrient deficiency among children in China:a systematic review of the literature[J].Public Health Nutr,2014,17(11):2605-2618.
[2] Spinas E,Saggini A,Kritas SK,et al.Can vitamin A mediate immunity and inflammation?[J].J Biol Regul Homeost,2015,29(1):1-6.
[3] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.反复呼吸道感染的临床概念和处理原则[J].中华儿科杂志,2008,46(2):108-110.
[4] 李廷玉.维生素A缺乏的诊断、治疗及预防[J].中华实用儿科临床杂志,2013,28(19):1519-1520.
[5] 冯战桂,张国英,刘荣添.反复呼吸道感染患儿免疫功能的研究[J].中华妇幼保健杂志,2013,28(11):1749-1750.
[6] Rajeev R,Bart GJ,Sherri LS,et al.Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A[J].PLoS One,2014,9(1):e86554.
[7] 王卫平.维生素A营养对儿童免疫功能的影响--透视儿童营养与免疫的关系[J].中华儿科杂志,2006,44(1):3-6.
[8] 钱力,鲁继荣,鲁莹.反复呼吸道感染患儿IgG亚类及维生素A水平的关联研究[J].中国妇幼保健杂志,2007,22(36):5201-5202.
[9] Thornton KA,Mora-Plazas M,Villamor E,et al.Vitamin A deficiency is associated with gastrointestinal and respiratory morbidity in school-age children[J].J Nutr,2014,144(4):496-503.
[10] Kartasurya MI,Ahmed F,Subagio HW,et al.Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia[J].Br J Nutr,2012,108(12):2251-2260.
[11] 刘敬涛,吴方银,赵梓伶,等.2010年四川省儿童血清维生素A水平分析[J].现代预防医学,2012,39(17):4403-4405.
[12] 彭容,魏小平,梁小华,等.重庆市巴南地区学龄前儿童膳食维生素A摄入量与血浆维生素A的关系[J].北京大学学报:医学版,2014,46(3):366-372.
[13] Amaral CT,Pontes NN,Maciel BL,et al.Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection[J].Pediatr Pulmonol,2013,48(5):481-489.
PDF(427 KB)
