Objective To observe serum visfatin level in children with type 1 diabetes mellitus (T1DM) and children with T1DM combined with ketoacidosis and investigate the correlation between serum visfatin level and glucolipid metabolism and islet β-cell function of these children. Methods From June 2010 to June 2014,82 children with T1DM who visited doctors in the Outpatient Department and hospitalized in Guangyuan Center Hospital,and 31 healthy controls were enrolled.Children with only newly diagnosed T1DM were assigned into T1DM I group (n=61),and children with T1DM combined with ketoacidosis were assigned into T1DM Ⅱ group (n=21).Comparisons were analyzed made in serum visfatin level,FPG,Fins,TC,TG,HDL-C,LDL-C,FFA,HbAlc,BMI and WHR among the three groups.Single-factor correlation analysis was conducted between serum visfatin level and other monitoring indexes of T1DM I group and T1DM Ⅱ group,and multivariate regression analysis of the correlation between serum visfatin level and other relevant factors was also conducted. Results 1)T1DMI group was lower than normal control group in serum visfatin level(P<0.01),and T1DM Ⅱ group was lower than T1DM I group in serum visfatin level (P<0.01).2)Pearson correlation analysis showed that the serum visfatin levels of T1DM I group and T1DM Ⅱ group were positively correlated with BMI,WHR,HDL-C,Fins,Homa-β,and were negatively correlated with TC,TG,LDL-C,FFA,FPG and HbAlc.Multivariate linear regression analysis showed that WHR,FFA,FPG and Homa-β of T1DM I group and T1DM Ⅱ group entered regression equation,which indicated that WHR,FFA,FPG and Homa-β were independent risk factors for serum visfatin level. Conclusion Children with T1DM and children with T1DM combined with ketoacidosis are lower than healthy controls in serum visfatin level,which may be related with the reduction of the fat content in viscera,glucose and lipid metabolism disorder and dysfunction of islet β-cell.
Key words
type 1 diabetes mellitus /
diabetic ketoacidosis /
glucolipid metabolism /
islet β-cell function
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