Association between exposure to o-phenylphenol during pregnancy and offspring size at birth

LIANG Wei-jiu; LV Shen-liang; GUO Jian-qiu; LU Da-sheng; WU Chun-hua; XU Hao; ZHOU Zhi-jun

doi:10.11852/zgetbjzz2016-24-02-08

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Chinese Journal of Child Health Care ›› 2016, Vol. 24 ›› Issue (2) : 137-140. DOI: 10.11852/zgetbjzz2016-24-02-08

Original Articles

Association between exposure to o-phenylphenol during pregnancy and offspring size at birth

LIANG Wei-jiu¹,LV Shen-liang²,GUO Jian-qiu²,LU Da-sheng³,WU Chun-hua²,XU Hao¹,ZHOU Zhi-jun²

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Abstract

Objective To assess the association between prenatal exposures to o-phenylphenol (OPP) and newborns' growth. Methods Questionnaires and spot urine samples were collected from 1 100 pregnant women living in a county of Jiangsu Province.Urinary concentrations of OPP were determined.Associations between maternal urinary concentration of OPP and neonate birth outcomes were investigated. Results Urinary OPP was detected in all samples,and the median values were 0.35 μg/L and 0.54 μg/g creatinine.Generalized linear model indicated that log-transformed OPP concentrations with creatinine correction were negatively associated with birth length (β=-0.670,P=0.006) and head circumference at birth (β=-0.505,P=0.001).OPP concentrations were negatively associated with length,weight and head circumference at birth among male newborns (P<0.05). Conclusion The findings suggest that the pregnant women are widely exposed to OPP in the studied county and urinary OPP concentrations of pregnant women are negatively associated with birth size among male newborns.

Key words

o-phenylphenol / exposure assessment / newborns / birth size

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LIANG Wei-jiu,LV Shen-liang,GUO Jian-qiu,LU Da-sheng,WU Chun-hua,XU Hao,ZHOU Zhi-jun. Association between exposure to o-phenylphenol during pregnancy and offspring size at birth[J]. Chinese Journal of Child Health Care. 2016, 24(2): 137-140 https://doi.org/10.11852/zgetbjzz2016-24-02-08

References

[1] 赵连俊.邻苯基苯酚的合成与应用研究进展[J].广州化工,2009,37(3):61-63.
[2] Coelhan M,Bromig KH,Glas K,et al.Determination and levels of the biocide ortho-phenylphenol in canned beers from different countries[J].J Agric Food Chem,2006,54(16):5731-5735.
[3] 杨涛,艾尔肯,依不拉音,等.反相高效液相色谱法同时测定果蔬中6种防腐杀菌剂[J].食品科技,2008,33(9):245-247. [4] Peng X,Yu Y,Tang C,et al.Occurrence of steroid estrogens,endocrine-disrupting phenols,and acid pharmaceutical residues in urban riverine water of the Pearl River Delta,South China[J].Sci Total Environ,2008,397(1-3):158-166.
[5] Kwok E,Silva M.Re-evaluation of developmental and reproductive toxicity of Ortho- Phenylphenol (OPP) and Sodium Ortho-Phenylphenate (SOPP)[J].Cell Dev Biol,2013,123(2):1-12.
[6] 王杰,赵丽云,朴建华,等.2009年8省(市)婴儿出生基本状况结果分析[J].卫生研究,2011,40(2):238-239.
[7] Lu D,Feng C,Wang D,et al.Analysis of twenty phenolic compounds in human urine:hydrochloric acid hydrolysis,solid-phase extraction based on K2CO3-treated silica,and gas chromatography tandem mass spectrometry[J].Analytical and Bioanalytical Chemistry,2015,407(14):4131-4141.
[8] Yu Y,Huang Q,Wang Z,et al.Occurrence and behavior of pharmaceuticals,steroid hormones,and endocrine-disrupting personal care products in wastewater and the recipient river water of the Pearl River Delta,South China[J].J Environ Monit,2011,13(4):871-878.
[9] Lassen TH,Frederiksen H,Jensen TK,et al.Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot,morning,and 24-h urine samples[J].Environ Res,2013,126:164-170.
[10] Tefre DRK,Frederiksen H,Christensen JS,et al.Current exposure of 200 pregnant Danish women to phthalates,parabens and phenols[J].Reproduction,2014,147(4):443-453.
[11] Frederiksen H,Nielsen JK,Morck TA,et al.Urinary excretion of phthalate metabolites,phenols and parabens in rural and urban Danish mother-child pairs[J].Int J Hyg Environ Health,2013,216(6):772-783.
[12] Kojima M,Fukunaga K,Sasaki M,et al.Evaluation of estrogenic activities of pesticides using an in vitro reporter gene assay[J].Int J Environ Health Res,2005,15(4):271-280.
[13] Bomhard EM,Brendler-Schwaab SY,Freyberger A,et al.O-phenylphenol and its sodium and potassium salts:a toxicological assessment[J].Crit Rev Toxicol,2002,32(6):551-625.
[14] Sobolewski M,Conrad K,Allen JL,et al.Sex-specific enhanced behavioral toxicity induced by maternal exposure to a mixture of low dose endocrine-disrupting chemicals[J].Neurotoxicology,2014,45:121-130.