目的 探讨婴幼儿补充维生素D对小囟门儿童头围发育及Bayley智力测评结果的关系。方法 选择2010年1月-2011年11月在湖州市妇幼保健院体检的正常儿童118例作为观察对象, 分为小囟门组和正常对照组, 均给与维生素D, 分别在月龄3、12、18个月三个时间节点测量头围值, 同时在6、18个月两个时间节点做Bayley智力测试。结果 小囟门组与对照组儿童在3、12、18个月头围值差异均无统计学意义(P>0.05);两组与相应年龄小儿头围正常值比较差异无统计学意义(P>0.05);两组儿童6、18个月Bayley智力测试结果均为正常。结论 服用预防剂量的维生素D不会影响小囟门儿童头围的发育及智能发育, 无论前囟大小均应服用预防剂量的维生素D。
Abstract
Objective To observe the influence of vitamin D supplementation on small fontanel pediatric growth of head circumference and Bayley intelligence test results. Methods 118 healthy infants aged 3months hospitalized in our Hospital from January 2010 to November 2011 were selected as the objects of the study.They were divided into two groups according to the fontanel inclined length.one was small fontanels group, the other was normal group.All infants were treated with vitamin D to prevent rickets.the head circumference of them were measured three points at 3 months, 12 months, 18 months and at 6 months, 18months the two points respectively Bayley intelligence test to evaluation analysis of their correlation. Results There were no statistically significant differences in the values of head circumference between the two groups at the age of 3 months, 12 months, 18 months and the values of head circumference between the two groups and the corresponding age of pediatric were not statistically significant different.Bayley intelligence test Results in two groups of the children at 6 months, 18 months were normal. Conclusions Vitamin D has no adverse effect on the skull growth of children with small anterior fontanel.It is necessary to take vitamin D for rickets prevention whatever the size of anterior fontanel.
关键词
维生素D /
小囟门 /
头围发育 /
Bayley智力测评
Key words
vitamin D /
small fontanel /
growth of head circumference /
Bayley intelligence test
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Kiesler J, Ricer R.The abnormal fontanel[J].Am Fam Physician, 2003, 67(12):2547-2552.
[2] WHO, Multicenter Growth Reference Study Group.WHO child growth standards:head circumference-for-age, arm circumference-for-age, triceps skinfold-for-age and subscapular skinfold-for-age:methods and development[R/OL].Geneva:World Health Organization.[2007-06-01].http://www.who.int/zh.
[3] 叶莉莉, 高玲娟, 顾平清, 等.南京市2812例0~6岁婴幼儿25-羟维生素D检测分析[J].国际检验医学杂志, 2012 , 33(16):1979-1980.
[4] 郝新忠, 黄之杰, 程莹, 等.成都市0~6岁儿童25-羟维生素D水平调查[J].中国妇幼保健, 2013, 28(5):819-822.
[5] 张霞娟, 鲍莉芳, 鲍舟君, 等.儿童血清 25-羟维生素D及钙磷水平调查[J].浙江预防医学, 2012, 24(6):5-7.
[6] 胡亚美, 江载芳.诸福棠实用儿科学[M].7版.北京人民卫生出版社, 2002:43.
[7] 吴婷, 黎海芪.0-2岁儿童前囟发育研究[J].中华儿科杂志, 2012, 50(7):493-497.
[8] Liptak GS, Serletti JM.Pediatric approach to craniosynostosis[J].Pediatrics in Review, 1998, 19:352-359.
[9] 任淑红.维生素D对前囟门偏小儿童头颅生长的影响研究[J].实用预防医学, 2012, 19(4):567-568.
[10] Pedroso FS, Rotta N, Quintal A, et al.Evolution of anterior fontanel size in normal infants in the first year of life[J].Child Neurol, 2008, 23:1419-1423.
[11] 崔朝晖.婴儿小囟门与头围及智能发育关系的临床探讨[J].上海预防医学杂志, 2002, 14(3):127.
[12] Wang J, Li H, He Q, et al.Effects of calcium and vitamin D supplementation on bone specific alkaline during pregnancy lactation and infant[J].Wei Sheng Yan Jiu, 2009, 38(2):193-195.
[13] Gernand AD, Simhan HN, Klebanoff MA, et al.Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a US multicenter cohort study[J].Clin Endocrinol Metab, 2013, 98(1):398-404.
[14] Kalra P, Das V, Agarwal A, et al.Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant[J].Br J Nutr, 2012, 108(6):1052-1058.