关键词: 苯丙酮尿症, 家庭环境, 母亲心理状况, 行为问题, 学龄前儿童

Abstract: Objective To analyse the relationship between behavior problem of children with phenylketonuria and the family environment and the psychological condition of their mothers,and to seek better treatment options. Methods A total of 32 children with phenylketonuria were detected by neonatal screening in Qingdao compared to 42 matched children.Family Environment Scale-Chinese Version(FES-CV),Symptom Check List-90(SCL-90) and Conners Parent Symptoms Questionnaire(PSQ) were used to investigate the related factors of the two groups. Results 1)In the comparison of PSQ,the scores of conduct problems,learning problems,impulse-hyperactivity and hyperactivity index in phenylketonuria children were higher than those of the control (P＜0.05).2)Correlation analysis showed that there were a negative correlations between behavior problems of phenylketonuria children and intimacy,achievement orientation,knowledge,entertainment,sense of organization as well as control factor of family.3)Psychosomatic disorder of phenylketonuria children was negative related to somatization of their mothers. Conclusions There are many behavior problems in preschool phenylketonuria children.Measures to improve the family environment and psychological intervention to phenylketonuria children and their mothers can help to promote the therapeutic effect of the phenylketonuria children.

Key words: phenylketonuria, family environment, mother's mental health, behavior problem, preschool children