关键词: 抵抗素, 妊娠期糖尿病, 新生儿, 脐动脉, 脂联素, 瘦素

Abstract: Objective To detect the levels of resistin,adiponectin and leptin in the umbilical artery plasma of infants born to mothers with gestational diabetes,and preliminarily to study the factors of affecting fetal growth and development. Methods Thirty-three babies born to diabetic mothers were clinically selected as study group,another 30 normal full-term newborn as control group.Resistin,adiponectin and leptin levels in cord serum were measured for all of the subjects by enzyme-linked immunosorbent assay.The indicators of growth and development in study group were accurately measured.The results were analyzed by using SPSS16.0 software. Results Resistin and adiponectin content of cord serum in study group was lower than in the control group,the difference was statistically significant (P<0.001).Leptin level was higher than the control goup(P<0.001).Resistin content was negatively correlated with wegiht,ponderal Index and leptin (r=-0.673,-0.563,-0.412,P＜0.05),and positively correlated with adiponectin content (r=0.397,P=0.003). Conclusions There might be some relationship between resistin with adiponectin,leptin in umbilical artery plasma of infants with diabetic mothers,and resistin may be related to the regulation of fetal growth and development.

Key words: gestational diabetes, newborns, umbilical artery, adiponectin, leptin, resistin